5. Chen, H., Sirupangi, T., Wu, Z.-H., Johnson, D. L. & Laribee, R. N. The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function. Sci. Rep. 8, 8163 (2018).6. Cano, F., Miranda-Saavedra, D. & Lehner, P. J. RNA...
近日,来自美国加州大学伯克利分校的Michael Rapé课题组在Nature上发表了研究论文Stress response silencing by an E3 ligase mutated in neurodegeneration,该研究揭示了上述问题,他们发现应激反应沉默是一个活跃的调节过程,主要是通过一个E3连接酶复合物降解未导入的线...
5. Chen, H., Sirupangi, T., Wu, Z.-H., Johnson, D. L. & Laribee, R. N. The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function. Sci. Rep. 8, 8163 (2018). 6. Cano, F., Miranda-Saavedra, D. & Lehner, P. J. R...
the loss of E3 ubiquitin ligase function enhances the tolerance of salt and drought stress, whereas overexpression increases sensitivity. A model is presented
来自美国罗格斯大学的Zhaohui Feng团队在JCI上发表题为“The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer”的研究成果,该研究揭示了 mutp53 在癌症中积累的关键机制,揭示了 TRIM21 的抑癌...
5. Chen, H., Sirupangi, T., Wu, Z.-H., Johnson, D. L. & Laribee, R. N. The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function. Sci. Rep. 8, 8163 (2018). 6. Cano, F., Miranda-Saavedra, D. & Lehner, P. J. ...
1.As key members of the protein degradation enzymatic system, the function of E3 ubiquitin ligases has been extensively investigated.作为该系统中行使调控降解功能的核心成员,E3泛素连接酶的重要作用已经越来越引起人们的重视。 英文短句/例句 1.Overexpression of E3 Ubiquitin Ligase CHIP Induces Mitotic Catastr...
Key words: plant pathology; RING; E3 ubiquitin ligase; stress resistance; disease resistance 0 引言泛素是一个由 76 个氨基酸残基组成的高度保守的多肽,广泛分布于各类细胞,被泛素标记的蛋白质将被特异性识别,其中多聚泛素化的蛋白将被特异性降解从而调控细胞周期,信号传导,DNA 修复,细胞凋亡等过程。而单泛素...
Key words: SINA E3 ubiquitin ligase ;growth and development ;abiotic stress ;interactions between organisms ;autophagy 泛素 - 蛋白酶体系统(ubiquitin-proteasome system,UPS)是真核生物细胞中重要且广泛存在的 蛋白平衡调节系统,通过介导细胞中错误折叠,受 损伤,寿命较短的特别是具有调节作用的蛋白质(转 录因子...
Therefore, a goal of future studies will be to determine whether calcium influx within single dendritic spines might regulate local E3 ubiquitin ligase function in vivo. • Recent studies have demonstrated that polyubiquitin chains conjugated onto substrates exist in several unique conformations, of ...