5. Chen, H., Sirupangi, T., Wu, Z.-H., Johnson, D. L. & Laribee, R. N. The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function. Sci. Rep. 8, 8163 (2018).6. Cano, F., Miranda-Saavedra, D. & Lehner, P. J. RNA...
The E3 ubiquitin ligase Ube3A was initially isolated as a cellular factor required for the transforming activity of human papillomavirus; however, subsequent studies have implicated this gene in aspects of human cognitive function. Maternal deficiency of Ube3A gives rise to Angelman syndrome (AS), a...
N. The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function. Sci. Rep. 8, 8163 (2018).6. Cano, F., Miranda-Saavedra, D. & Lehner, P. J. RNA-binding E3 ubiquitin ligases: novel players in nucleic acid regulation. Biochem. Soc...
来自美国罗格斯大学的Zhaohui Feng团队在JCI上发表题为“The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer”的研究成果,该研究揭示了 mutp53 在癌症中积累的关键机制,揭示了 TRIM21 的抑癌...
E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. J. H. Jung,S. Bae,J. Y. Lee. Cell Death and Differentiation . 2011Jung JH, Bae S, Lee JY et al (2011) E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. Cell Death Differ 18, ...
Polycomb repressive complex 1 (PRC1) is the E3 ubiquitin ligase responsible for the majority of ubiquitin incorporation at the C-terminus of histone H2A (H2A) (lysines 118/119). Accordingly, PRC1 ligase function has been the subject of recent biochemical and structural studies. The E3 activity...
5. Bachmair, A., Finley, D. & Varshavsky, A. In vivo half-life of a protein is a function of its amino-terminal residue.Science234, 179–186 (1986). 6. Koren, I. et al. The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.Cell173, 1622–1635.e...
Andrews, P., He, Y. J. & Xiong, Y. Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function.Oncogene25, 4534–4548 (2006). ArticleCASGoogle Scholar Kohrman, D. C. & Imperiale, M. J. Simian virus 40 large T antigen stably comp...
近日,重庆医科大学感染性疾病分子生物学教育部重点实验室汪凯、唐霓和黄露义课题组在Oncogene在线发表了题为O-GlcNAcylation of E3 ubiquitin ligase SKP2 promotes hepatocellular carcinoma proliferation的研究论文【7】。该研究首次发现E3泛素...
Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCFTIR1 in Mediating Auxin Response The COP9 signalosome is an evolutionary conserved multiprotein complex of unknown function that acts as a negative regulator of photomorphogenic seedling d... Schwechheimer,C. - 《Science》 被引量...