【摘要】为了研究儿童急性淋巴细胞白血病(ALL)中E2A-PBX1融合基因的表达,采用位于E2A基因不同位置的上游引物与下游PBX1引物,检测了410例儿童ALL,包括362例B细胞ALL和48例T细胞ALL.结果发现:17例患儿携带E2A-PBX1融合基因,检出率4.1%,且全部为B细胞ALL,而且所有阳性病例均表达一种变异型融合转录本,后者是由E2A基...
Objective: The objective of this study was to observe the prognosis of pediatric patients with E2A-PBX1-positive acute lymphoblastic leukemia (ALL) from the treatment with the CCLG-ALL2008 protocol. Design and methods: Three hundred and forty-nine Chinese pediatric patients with pr...
To address this, we interrogated activated signaling pathways in a comparative analysis of mouse and human leukemias expressing the fusion protein E2A-PBX1, which is present in 5%-7% of pediatric and 50% of pre-B-cell receptor (preBCR + ) acute lymphocytic leukemia (ALL). In this study, ...
In this study, an antiserum to Pbx1 was used to investigate the identity and abundance of E2A-Pbx1 fusion proteins in both the pre-B ALL cell line... Mark P. Kamps,AT Look,D Baltimore - 《Genes & Development》 被引量: 369发表: 1991年 Both Pbx1 and E2A-Pbx1 bind the DNA motif...
The t(1;19)(q23;p13) is the most common recurring translocation in childhood ALL.1 It was first described by Carroll et al3 in 1983 as a nonrandom translocation associated with pre—B-cell ALL (lymphoblasts which express cytoplasmic, but not surface, Ig4). Subsequently, studies of the ...
B-cell acute lymphoblastic leukemia (B-ALL) accounts for the most cancer incidences in children. We present here that autophagy is downregulated in pediatric B-ALL, suggesting a possible link between autophagy failure and pediatric B-ALL leukemogenesis.
SETDB2 E2A-PBX1 CDKN2C preB-ALL acute leukemia cell-cycle inhibition Introduction Acute lymphoblastic leukemia (ALL) is associated with significant morbidity and mortality in adults and children, despite ongoing improvements in diagnosis and therapy. ALLs are subcategorized based on their karyotype, ...
Myers, Rational design of an immunoconjugate for selective knock-down of leukemia-specific E2A-PBX1 fusion gene expression in human Pre-B leukemia, Integr. Biol. 5 (2013) 122- 132.F.M. Uckun, S. Qazi, I. Dibirdik, D.E. Myers, Rational design of an immunoconjugate for selective ...
To investigate the clinical characteristics of E2A-PBX1 (immunoglobulin enhancer binding factor-pre-B leukemia) fusion gene in patients with acute lymphoblastic leukemia (ALL) after allogeneic stem cell transplantation (allo-HSCT). Methods Clinical data of 10 patients received allo-HSCT in Peking ...
【摘要】为了研究儿童急性淋巴细胞白血病(ALL)中E2A-PBX1融合基因的表达,采用位于E2A基因不同位置的上游引物与下游PBX1引物,检测了410例儿童ALL,包括362例B细胞ALL和48例T细胞ALL.结果发现:17例患儿携带E2A-PBX1融合基因,检出率4.1%,且全部为B细胞ALL,而且所有阳性病例均表达一种变异型融合转录本,后者是由E2A基...