【摘要】为了研究儿童急性淋巴细胞白血病(ALL)中E2A-PBX1融合基因的表达,采用位于E2A基因不同位置的上游引物与下游PBX1引物,检测了410例儿童ALL,包括362例B细胞ALL和48例T细胞ALL.结果发现:17例患儿携带E2A-PBX1融合基因,检出率4.1%,且全部为B细胞ALL,而且所有阳性病例均表达一种变异型融合转录本,后者是由E2A基...
cases of pre-B cell-derived human ALL, we found that pre-B cell receptor expression and function is linked to specific cytogenetic subgroups: ALL cells carrying an E2A-PBX1-gene rearrangement are, like normal pre-B cells, highly selected for the expression of a functional pre-B cell ...
The translocation of(1; 19)(q23; p13)leading to E2A-PBX1 gene fusion, is one of the most common translocations in pediatric B-ALL.Fusion of the E2A-PBX1 gene forms a specific transcription factor activating the pre-B cell receptor, allowing the pre-B cells to self-renew.This process...
The E2A-Pbx1 oncoprotein that results from the t(1;19) chromosomal translocation of childhood pre-B cell acute lymphoblastic leukemia (pre-B ALL) is a fascinating oncoprotein because it blocks differentiation and physically interacts with homeodomain proteins, which are effectors of normal ...
SETDB2 E2A-PBX1 CDKN2C preB-ALL acute leukemia cell-cycle inhibition Introduction Acute lymphoblastic leukemia (ALL) is associated with significant morbidity and mortality in adults and children, despite ongoing improvements in diagnosis and therapy. ALLs are subcategorized based on their karyotype, ...
Myers, Rational design of an immunoconjugate for selective knock-down of leukemia-specific E2A-PBX1 fusion gene expression in human Pre-B leukemia, Integr. Biol. 5 (2013) 122- 132.F.M. Uckun, S. Qazi, I. Dibirdik, D.E. Myers, Rational design of an immunoconjugate for selective ...
【摘要】为了研究儿童急性淋巴细胞白血病(ALL)中E2A-PBX1融合基因的表达,采用位于E2A基因不同位置的上游引物与下游PBX1引物,检测了410例儿童ALL,包括362例B细胞ALL和48例T细胞ALL.结果发现:17例患儿携带E2A-PBX1融合基因,检出率4.1%,且全部为B细胞ALL,而且所有阳性病例均表达一种变异型融合转录本,后者是由E2A基...
The present invention also encompases the production and use of monoclonal antibodies specific for pbx1 as a diagnostic reagent for pre-B cell acute lymphoblastic leukemia (ALL) arising from the t(1;19) (q23,pl3.3) chromosomal translocation. The protein pbx1 is expressed in all tissues except...
The primers located at different sites of E2A and PBX1 gene were used to screen for the fusion gene in 410 children with ALL,including 362 cases of B cell ALL and 48 cases of T cell ALL. The results showed that 17 children carried the fusion gene. The positive rate was 4.1%. ...
Objective: The objective of this study was to observe the prognosis of pediatric patients with E2A-PBX1-positive acute lymphoblastic leukemia (ALL) from the treatment with the CCLG-ALL2008 protocol. Design and methods: Three hundred and forty-nine Chinese pediatric patients with pr...