骨髓微环境 (bone marrow microenvironment,BMM) 在白血病进展中起关键作用,但其在pre-B 细胞急性淋巴细胞白血病 (B-ALL)(儿童最常见的癌症)中的分子复杂性仍知之甚少。为了进一步了解,本文使用单细胞 RNA 测序来表征 B-ALL 进展过程中鼠 BMM 的变化。发现pre-B 细胞在疾病的早期阶段受影
Reid,-G-S; Terrett,-L; Alessandri,-A-J; et al Altered patterns of T cell cytokine production induced by relapsed pre-B ALL cells.Leuk-Res. Dec; (2003): 27(12):1135-42.Reid GS, Terrett L, Alessandri AJ, Grubb S, Stork L, Seibel N et al. Altered patterns of T cell cytokine...
ALLBtkThe adapter protein Slp65 and Bruton's tyrosine kinase (Btk) are key components of the precursor-B (pre-B) cell receptor (pre-BCR) signaling pathway. Slp65-deficient mice spontaneously develop pre-B-cell leukemia, expressing high levels of the pre-BCR on their cell surface. As ...
Hailong Li1,2 & Shinghua Ding1,2 We previously demonstrated that Pre-B-cell colony-enhancing factor (PBEF), also known as nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in mammalian NAD+ biosynthesis pathway, plays a brain and neuronal protective role in ischemic st...
Early in the development, expression of a pre-B-cell receptor (pre-BCR) that has membrane-bound Ig heavy chain protein associated with surrogate light chain (SLC) proteins serves as a critical checkpoint that monitors for functional heavy chain rearrangement. Signaling from the pre-BCR induces ...
The λ5 gene is expressed exclusively in precursor (pre-) B cells where its gene product, as part of the pre-B cell receptor, is crucial for the proliferation of these cells. Several DNA regions regulate the activity and expression pattern of the λ5 gene. Amongst these is an en...
theIgklocus has a similar TAD structure in both pre-B cell types (Fig.1d). We next performed Hi-C analysis withIghB1-8hi/+Rag2–/–pre-B cells, which were generated in the absence of V(D)J recombination due to RAG2 loss by skipping the pro-B cell stage through the expression of...
B cell antigen receptor(BCR) signaling initiates sustained cellular calcium influx necessary for the development, differentiation and activation of B-lymphocytes. B细胞抗原受体(BCR)信号传导起始于持续的钙离子向细胞内流动,这种钙离子的内流对于B细胞的生长、分化、活化是必需的。4...
We report a case of a 66-year-old man with a history of ET, lacking mutations in Janus kinase 2 (JAK2), Calreticulin (CALR), or myeloproliferative leukemia virus oncogene (MPL), who subsequently developed Philadelphia chromosome (Ph)-positive B-cell ALL (B-ALL), harborin...
网络前B细胞克隆增强因子 网络释义 1. 前B细胞克隆增强因子 前B细胞克隆增强... ... ) myocyte enhancer factor 肌细胞增强因子 )Pre-B cell colony-enhancing factor前B细胞克隆增强因子... www.dictall.com|基于3个网页