网络类药属性 网络释义 1. 类药属性 2.4.1.2类药属性(Drug-like property)50-52 2.4.1.3 生物药剂学分类系统(Biopharmaceutics classification systerm, BCS)52 2.4.2... cdmd.cnki.com.cn|基于 1 个网页
如今有一种新型的筛选方式为SPR(structure-property relationships),算作对SAR的补充:一方面利用SAR(一种structure-based design)设计出高亲和力的化合物,再利用SRP(一种property-based design)的方式得到能顺利通过各种屏障、达到靶点的化合物。 Pharmaceuticals balance activit...
Through valuable case studies, structure-property relationship descriptions, and structure modification strategies,Drug-Like Properties, Second Edition,offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. ...
Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property ...
applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties....
Property design has become an integrated and inseparable part of the modern drug discovery paradigm. The approach has been proven to be a winning strategy.LiChemicalDiChemicalKernsChemicalEdwardChemicalH.ChemicalCarterChemicalGuyChemicalT.Chemical
Drug-Like Property Concepts in Pharmaceutical Design The pharmaceutical industry is facing an ever increasing challenge to deliver safer and more effective medicines. Traditionally, drug discovery programs we... D Li,K Edward,C Guy - CPD 被引量: 106发表: 2009年 The influence of drug-like concept...
property distributions of drug-like compounds, non-drug-like compounds and natural compounds fr... Background In this work, we analyzed and compared the distribution profiles of a wide variety of molecular properties for three compound classes: drug-like... M Shen,S Tian,Y Li,... - 《...
Chemical probes Combinatorial chemistry Computer chemistry Database filtering Druglike Drug research Hydrogen bonds Lead discovery Leadlike MLSCN MLSMR Molecular complexity Property distribution Pub-like PubChem “Rule of 5” test WOMBAT DOI: 10.1007/s10822-007-9105-3 ...
These rules are a set of property values that were derived from classifying the key physicochemical properties of drug compounds. Drug-like molecules, ... D Lagorce,O Sperandio,H Galons,... - 《Bmc Bioinformatics》 被引量: 224发表: 2008年 Lossless Compression of Chemical Fingerprints Using In...