网络类药属性 网络释义 1. 类药属性 2.4.1.2类药属性(Drug-like property)50-52 2.4.1.3 生物药剂学分类系统(Biopharmaceutics classification systerm, BCS)52 2.4.2... cdmd.cnki.com.cn|基于 1 个网页
曾有人在公司内报告过关于Drug-like的故事,现在没有多少印象,多半是因为当时很多知识并不了解,无法真正体会其中含义,要么就是药物的研发的领域实在是过于庞大,一般需要了解一个化合物的诸多特性才可进入临床试验:如结构的特征,包括分子量、氢键结合、极性、构型、亲脂性...
Through valuable case studies, structure-property relationship descriptions, and structure modification strategies,Drug-Like Properties, Second Edition,offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. ...
Di, L.; Kerns, E.H.; Carter, G.T. Drug-like property concepts in pharmaceutical design. Curr. Pharm. Des. 2009, 15, 2184-2194.L. Di, E.H. Kerns, G.T. Carter. Drug‐like property concepts in pharmaceutical design. Current Pharmaceutical Design 15 (2009) 2184‐2194....
* Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint Drug-like Properties 2024 pdf epub mobi 电子书 ...
It is important to note that clinical drug development failure due to poor drug-like properties has been significantly improved in the past 20 years29, which suggests the right strategy in drug-like property optimization. However, overall success rate of clinical drug development has not been signi...
DBPP-Predictor: a novel strategy for prediction of chemical drug-likeness based on property profiles Yaxin Gu Yimeng Wang Yun Tang Journal of Cheminformatics (2024) Reaping the benefits of liquid handlers for high-throughput gene expression profiling in a marine model invertebrate Giovanni Annona...
Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property Includes a new chapter on the discovery and develo...
Drug-likeness, a qualitative property of chemicals assigned by experts committee vote, is widely integrated into the early stages of lead and drug discovery. Its conceptual evolution paralleled work related to Pfizer's rule of five and lead-likeness, and is placed within this framework. The discri...
those molecules must be shown to have properties enabling them to act like a medicine when given to people. The molecules must have pharmacokinetic (PK) properties that enable there to be a predictable and consistent relationship between the dose of the drug given, exposure of the drug at the...