Targeting Drug Transporter Mrp4 Increases Topotecan Accumulation in the CNSgastric carcinomaadjuvant chemoradiotherapyhepatic toxicityhepatitis B viral reactivationA protein called Mrp4 blocks the access of the anti-cancer drug topotecan into the brain by transporting this agent back into the bloodstream, ...
Senescent cells accumulate throughout the body with advanced age, diseases and chronic conditions. They negatively impact health and function of multiple systems, including the central nervous system (CNS). Therapies that target senescent cells, broadly
we summarize key trends in peptide drug discovery and development, covering the early efforts focused on human hormones, elegant medicinal chemistry and rational design strategies, peptide drugs derived from nature, and major breakthroughs in molecular biology and peptide chemistry that continue to advance...
N. et al. Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle 10, 4230–4236 (2011). CAS PubMed Google Scholar Popovich, I. G. et al. Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses...
that the vast majority of3H-THK5351 signal was blocked with MAO-B inhibitor lazabemide [54]. This study is consistent with the in vivo data discussed above and provides strong evidence of off-target binding to MAO-B. MAO-B is prevalent across the entire brain, increases with age, has ...
The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologicals...
such as the wide distribution of drugs throughout the body. This approach increases the specific affinity of the active molecule to the lesion, thereby avoiding nonspecific toxicity and other adverse side effects associated with high doses of the drug. As such, nanomedicine is viewed as a highly...
42,43 We found greater increases in risk associated with people diagnosed with dementia before the age of 80, which indicates that anticholinergic drugs should be prescribed with caution in middle-aged and older people. Back to top Article Information Accepted for Publication: February 19, 2019 ...
Cimetidine: Increases the effect of the narcotic. Triprolidine: The CNS depressants, Triprolidine and Nalbuphine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy. Hepatic Dose : ...
The neutral molecules are considered to be the dominant form that permeates lipid membranes by passive diffusion, because neutral molecules are much more lipophilic than the ionized molecules. Thus, as the fraction of ions in solution increases, the apparent permeability decreases. The effects of ...