Drugs acting on CNS: Selected topics in experimental pharmacology. Bombay: Mohanlal B. Kothari Book Depot; 1972.Seth UK, Dadkar NK, Kamt UG. Bombay: Mohanlal B. Kothari Book Depot; 1972. Drugs acting on CNS: Selected topics in experimental pharmacology....
To date, there is no conclusive evidence on the role of RAS and ACE-2 in the three stages of SARS-CoV-2 infection. Drugs acting on RAS are widely used in the treatment of cardiovascular diseases, but what is the correlation between these drugs, RAS, and COVID-19? Could they have a ...
AstraZeneca plans the first regulatory filings based on the program in 2013. References 1Reimer, K et al. Meeting the challenges of opioid-induced constipation in chronic pain management – a novel approach. Pharmacology. 2009; 83:10-17. 2IMS MAT. December 2010. 3Johanson, JF and Kraltein,...
respectively [1]. An imbalance in their activity has been associated with abnormal neuronal firing and can under certain conditions contribute to the pathogenesis of several CNS disorders, including epilepsy. Drugs
PharmacologyAspirin: Inhibits prostaglandin synthesis by decreasing the activity of the enzyme, cyclooxygenase, which results in decreased formation of prostaglandin precursors, acts on the hypothalamic heat-regulating center to reduce fever, blocks thromboxane synthetase action which prevents formation of the...
Midazolam, which enhances the action of GABA on the GABAAreceptors, is preferred because it is fast-acting and has a short duration of action. In a study of 27 children with RSE, 0.2 mg/kg of midazolam was given as a bolus dose followed by 1–5 µg/kg/min of continuous midazolam ...
PharmacologyCauses increased availability of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, to brain neurons or may enhance the action of GABA or mimic its action at postsynaptic receptor sites. Also blocks voltage-dependent sodium channels, which results in suppression of high-frequency...
or different lots of drug substance, results were summarized into 121 097 unique drug vs. assay pairs. The number of assays per drug ranged from 20 to 161, with a median of 66. Thus, SPD represents an unprecedented resource for investigating on- and off-target pharmacology of marketed drugs...
Note: CNS: Central Nervous System, N/A: Not Available, NCT Number is the ClinicalTrials.gov identifier. 4.2. Lithium Lithium salt is a first-line drug for the treatment of bipolar disorder. Despite its toxic side effects such as nausea, diarrhea, polyuria, polydipsia, tremor, and cognitive...
M. et al. A new class of synthetic antibacterials acting on lipopolysaccharide biosynthesis. Nature 327, 730–732 (1987). CAS PubMed Google Scholar Kullak-Ublick, G. A. et al. Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. ...