Cytochrome P450 (P450 or CYP) enzymes are the major catalysts of oxidation of all drugs. Of the 57 human P450, 2/3 have been demonstrated to be capable of oxidizing or reducing some drugs but P450s 1A2, 2C9, 2C19, 2D6, and 3A4 are involved in most drug oxidations. Some other ...
Here we review the recent progress on drug metabolism activity profiles, interindividual variability and regulation of expression, and the functional and clinical impact of genetic variation in drug metabolizing P450s. 展开 关键词: Biotransformation Cytochrome \{P450\} monooxygenase NADPH:cytochrome \{...
The cytochrome-P450 (CYP) enzyme system is involved in the metabolism and elimination of numerous widely used drugs. The capacity of this system varies from one person to another, leading to variable drug excretion rates and intersubject differences in the final serum drug concentrations. Due to ...
Metabolism of drugs takes place through two different consecutive phases named “phase I” and “phase II”. Cytochrome P450s (CYPs) are major Phase I enzymes while glutathione-S-transferases (GSTs), and UDP-glucuronosyltransferases (UGTs), are the major enzymes belonging to Phase II enzymes...
Prediction of drug-drug interactions due to cytochrome P450 isoform 3A4 (CYP3A4) overexpression is important because this CYP isoform is involved in the me... H Vermet,N Raoust,R Ngo,... - 《Drug Metabolism & Disposition》 被引量: 11发表: 2015年 Non-Dissociative Sequential Metabolism of ...
3. Expression of particular isoforms of cytochrome P450In this contribution an overview about the P450s partici-pating in xenobiotics metabolism is given with focus on those like CYP1B 1(CYP2B6)CYP2E1,and CYP3As that are not covered in other contributions to this series. ...
R Hyland,BC Jones,DA Smith - 《Drug Metabolism & Disposition》 被引量: 743发表: 2003年 Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms. The CYP51 family is an intriguing subject for fundamental P450 structure/function studies and is also an important cli...
Activation of the Acute Inflammatory Response Alters Cytochrome P450 Expression and Eicosanoid Metabolism. Drug Metab. Dispos. 2011, 39, 22–29. [Google Scholar] [CrossRef] [Green Version] Sehgal, N.; Agarwal, V.; Valli, R.K.; Joshi, S.D.; Antonovic, L.; Strobel, H.W.; Ravindran...
Thrombin是血小板最有效的生理活化剂,其可刺激血小板表面的PAR-1及PAR-4受体,进而激活血小板内部的信号通路,导致血小板聚集。AA是血小板内TXA2的前体,其通过环氧化酶和血栓素合成酶转化为TXA2,进而导致颗粒释放及更多TXA2生成、持续激活GPIIb/IIIa并诱导血小板聚集[11]。在进行血小板聚集实验时,可根据化合物的作用靶点/...
Cytochrome P450 enzymes are found in all life forms. P450s play an important role in drug metabolism, and have potential uses as biocatalysts. Human P450s are membrane-bound proteins. However, the interactions between P450s and their membrane environment are not well-understood. To date, all P4...