Hence a prolonged field potential duration could result in the prolongation of ventricular action potential and could indicate a prolongation of the QT interval recorded on the ECG. Drug-induced action potential prolongation should be distinguished from prolon...
Shah RR. Drug-induced QT interval prolongation: Regulatory perspectives and drug development. Ann Med. 2004;36(Suppl 1):47-52.Shah RR (2004) Drug-induced QT interval prolongation: regulatory perspectives and drug development. Ann Med 36 Suppl 1:47–52...
Acquired (Drug-Induced) Long and Short QT Syndromes This chapter is presented in two parts 鈥 QT interval prolongation and QT interval shortening. Part 1 begins with a historical perspective on the consequen... RR Shah,I Gussak - Springer London 被引量: 3发表: 2013年 [Novartis Foundation Sy...
摘要: The article relates the study which compares the QT prolongation of two quinolone antibiotics. There has been investigations on the drug-induced occurrence of quinolone antibiotics, a class of drugs that has been associated with inducing arrhythmias....
Delayed repolarization (manifest as prolongation of the QT interval) is a well-established surrogate marker for a rare but potentially lethal arrhythmia termed torsade de pointes (TdP). Numerous preclinical assays have been developed to detect liabilities associated with drug-induced delayed repolarization...
2. Roden DM. Drug-induced prolongation of the QT interval.N Engl J Med. 2004;350:1013-1022. 3. Yap YG, Camm AJ. Drug induced QT prolongation and torsades de pointes.Heart. 2003;89:1363-1372. 4. Darpo B. Spectrum of drugs prolonging QT interval and the incidence of torsades de poin...
药物QTofDrugQT间期drugint 系统标签: intervalprolongationdrug间期inducedqtc Original article Assessment of drug-induced QT interval prolongation in conscious rabbits A. Kijtawornrat a , Y. Ozkanlar b , B.W. Keene c,d , B.M. Roche c , D.M. Hamlin c , R.L. Hamlin a, * a Department ...
Heart failure (HF) with reduced ejection fraction (HFrEF) is a risk factor for drug-induced QT interval prolongation. It is unknown if HF with preserved ejection fraction (HFpEF) is also associated with an increased risk. Dofetilide and sotalol are potent QT interv...
As to amisulpride, after overdosage this drug has reportedly a similar risk of QT prolongation to that of thioridazine (Berling and Isbister, 2015). There are, however, very few unequivocal reports of fatal amisulpride poisoning (Isbister et al., 2006). Read more View chapterExplore book Fore...
Drug induced QT prolongation and torsades de pointes. Heart. 2003;89:1363–72. Article PubMed Central CAS PubMed Google Scholar Honig PK, Woosley RL, Zamani K, Conner DP, Cantilena Jr LR. Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant ...