[7] Woosley RL, Romero KA. QTdrugs List [EB/OL]. www.crediblemeds.org (最后更新时间2021-3-21). [8] Gupta A, Lawrence AT, Krishnan K, et al. Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes [J]. Am Heart J, 2007, 153:891–...
Drug-induced prolongation of cardiac repolarization may trigger malignant ventricular arrhythmias, such as torsade de pointes. The duration of QT interval,... Staikou,C.,Stamelos,... - 《Bja the British Journal of Anaesthesia》 被引量: 63发表: 2014年 Negative electro-mechanical windows are requi...
Domperidone-induced QT prolon- gation: add another drug to the list. Pediatr, 2008; 153: 596-598.Collins KK, Sondheimer JM. Domperidone-induced QT prolon- gation: add another drug to the list. J Pediatr 2008;153: 596e8.Collins KK, Sondheimer JM. Domperidone-induced QT prolongation: add ...
QT can vary with gender, time of day, food intake, alcohol intake, menstrual cycle, ECG lead placement Plasma levels can also change QTc prolongation is most prominent at peak drug plasma levels and least obvious at trough levels.QT-prolonging Medications...
Introduction Drug-induced QT-prolongation is an established risk factor for Torsade de pointes and sudden cardiac death. The list of QT-prolonging drugs is extensive and includes many drugs commonly used in psychiatry. Aim In this study we performed a cross-sectional analysis of medication profiles...
Shah RR (2004) Drug-induced QT interval prolongation: regulatory perspectives and drug development. Ann Med 36 Suppl 1:47–52Shah RR. Drug-induced QT interval prolongation: regulatory perspectives and drug development. Ann Med 2004; 36 (Suppl. 1): 47-52....
Since QT interval prolongation, a surrogate of torsade, is a mechanismbased concentrationdependent pharmacological effect, it is usually possible to characterise a drug for this toxicity during its development. The physicochemical and other pharmacological properties of a QTprolonging drug modulate its ...
5,31,32 Despite its limitations, QT prolongation continues to be an important metric of drug safety and is among the most common reasons for drug withdrawal and black-box warnings in the United States.5 Our results caution the use of consensus criteria in evaluating the association of QTPMs ...
During the past decade, a number of non-cardiovascular drugs have had their label revised or have been withdrawn from the market because of unexpected post-marketing reports of sudden cardiac death associated with a prolongation of the QT interval, and a
摘要: The article relates the study which compares the QT prolongation of two quinolone antibiotics. There has been investigations on the drug-induced occurrence of quinolone antibiotics, a class of drugs that has been associated with inducing arrhythmias....