Drug induced or acquired QT prolongation often represents a latent form of congenital long QT syndrome, though the genetic basis of this has not been elucidated in the majority of cases. Understanding this has lead to a new concept of repolarization reserve, a measure of inherent susceptilibili...
Shah RR. Drug-induced QT interval prolongation: Regulatory perspectives and drug development. Ann Med. 2004;36(Suppl 1):47-52.Shah RR (2004) Drug-induced QT interval prolongation: regulatory perspectives and drug development. Ann Med 36 Suppl 1:47–52...
摘要: The article relates the study which compares the QT prolongation of two quinolone antibiotics. There has been investigations on the drug-induced occurrence of quinolone antibiotics, a class of drugs that has been associated with inducing arrhythmias....
New perspectives in long QT syndrome expected and interestingly, ethnic specific polymorphism conferring increased susceptibility to drug induced QT prolongation and torsades de pointes have been ... A Medeiros-Domingo,P Iturralde-Torres,S Canizales-Quinteros,... - 《Revista De Investigación Clínica》...
2. Roden DM. Drug-induced prolongation of the QT interval.N Engl J Med. 2004;350:1013-1022. 3. Yap YG, Camm AJ. Drug induced QT prolongation and torsades de pointes.Heart. 2003;89:1363-1372. 4. Darpo B. Spectrum of drugs prolonging QT interval and the incidence of torsades de poin...
Delayed repolarization (manifest as prolongation of the QT interval) is a well-established surrogate marker for a rare but potentially lethal arrhythmia termed torsade de pointes (TdP). Numerous preclinical assays have been developed to detect liabilities associated with drug-induced delayed repolarization...
Hence a prolonged field potential duration could result in the prolongation of ventricular action potential and could indicate a prolongation of the QT interval recorded on the ECG. Drug-induced action potential prolongation should be distinguished from prolon...
药物QTofDrugQT间期drugint 系统标签: intervalprolongationdrug间期inducedqtc Original article Assessment of drug-induced QT interval prolongation in conscious rabbits A. Kijtawornrat a , Y. Ozkanlar b , B.W. Keene c,d , B.M. Roche c , D.M. Hamlin c , R.L. Hamlin a, * a Department ...
Heart failure (HF) with reduced ejection fraction (HFrEF) is a risk factor for drug-induced QT interval prolongation. It is unknown if HF with preserved ejection fraction (HFpEF) is also associated with an increased risk. Dofetilide and sotalol are potent QT interv...
Drug induced QT prolongation and torsades de pointes. Heart. 2003;89:1363–72. Article PubMed Central CAS PubMed Google Scholar Honig PK, Woosley RL, Zamani K, Conner DP, Cantilena Jr LR. Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant ...