Medication-induced QT prolongation commonly occurs through alterations of intracellular ion channels. Prolonged depolarization is associated with increased function of inward sodium channels (INa).7More often, medications reduce repolarization by inhibiting the outward potassium channels (IKr). Potassium and m...
Several factors influence the risk of drug-induced QT prolongation (Table 1). Female gender has been documented in many studies as a risk factor, with females having baseline QTc intervals that are generally 20 milliseconds greater than that of males.2,3Cardiac conditions such as bradycardia and ...
Finally, clinicians should keep in mind that syncope maybe the only symptom of PE and that PE maybe present even without cardiorespiratory symptoms, thromboembolic risk factors, desaturation on pulse oximetry, or peripheral ede...
Prolongation of this interval can lead to life-threatening complications. These can include arrhythmias such as Torsades de Pointes and Ventricular Fibrillation, which may ultimately lead to death. Many risk factors have been identified in prolonging the QT interval, one of which is medication ...
Given her history of syncope without prodromal symptoms, we suspected that this patient had fallen as a result of cardiogenic syncope relating to prolonged QT syndrome. Donepezil was withdrawn as the potentially causative medication. The 12 lead ECG was repeated at days 2 and 10, and the QTc ...
Respondents to the survey on LQTS were more likely to stop a QT-prolonging medication for a QT of 520 ms than for a QT of 500 ms. However, it should be emphasized that there is no clear-cut consensus on the degree of drug-induced QT prolongation that should require drug discontinuation....
The most important drug-induced form of proarrhythmia is acquired long QT syndrome (LQTS) and resulting potentially fatal polymorphic ventricular tachycardia termed torsades de pointes (TdP). Tremendous progress has been made in research on and understanding of mechanisms underlying QT prolongation and ...
All patients were free of cardiac symptoms and not taking any medication. The mean heart rate was 72 ± 13 bpm (range, 43-105 bpm), the mean QT interval was 394 ± 34 ms (range, 320-479 ms), and the mean QTc interval was 426 ± 21 ms (range, 367-458 ms) using the Bazett ...
These results suggest that P‐gp‐mediated interactions are a risk factor for antipsychotic‐induced QT prolongation. There is a need for further investigation into the risks of specific drug combinations. 展开 关键词: disproportionality analysis drug–drug interaction Japanese Adverse Drug Event Report ...
FIG. 8 shows the effects of Compound 1 in a different model of LQT-2 and drug-induced QT prolongation. E-4031 is an inhibitor of IKr. Compound 1 shortens the prolonged action potential duration (APD), QT interval and Tpeak to Tend (TpTe) that is prolonged by 60 nM E-4031 in the ...