Drug鈥揹rug interaction (DDI) can result when one drug alters the pharmacokinetics of another drug or its metabolites. The assessment of pharmacokinetic DDIs during clinical development is a part of the general clinical pharmacology and safety assessment of a new investigational compound. Market ...
Some drugs influence the gastro-intestinal absorption, distribution, metabolism or renal excretion of other drugs, i.e. processes involved in pharmacokinetic interactions. The clinical consequences of pharmacokinetic drug-drug interaction will be either an increase or a decrease in known therapeutic or to...
药物相互作用DRUG-DRUG INTERACTION.ppt,个体预测法 给药次序 先使用相互作用药(precipitating drug)待病情稳定后,给予目标药(index drug) ,除非停用相互作用药,否则不会出现相互作用 例如西咪替丁和香豆素类的相互作用 个体预 测 疗程 相互作用的发生时间长短不一致
Drug Interaction Facts, Drug-Reax, Lexi-Interact, Pharmavista, Stockley’s Drug Interactions, The Medical Letter and Vidal ,常用于处方 (用 药医嘱)的检查,以发现最具临床相关性的DDI Drug-Reax (Micromedex®) Lexi-Interact Pharmavista 信息系统识别DDI 此外,一些其它的数据库也列出了已知的DDI,包括:Da...
相关概念相互作用对(interactionpair)能够引起药物效应变化的两个药物目标药物(objectdrug,orindexdrug)在联合用药中，药效发生变化的药物相互作用药物，促发药物(interactiondrug,orprecipitatingdrug)在联合用药中，引起其他药物发生变化的药物 2药物相互作用的研究对象 药物在体外和药物在体内的相互作用药物...
相关概念相互作用对(interactionpair)能够引起药物效应变化的两个药物目标药物(objectdrug,orindexdrug)在联合用药中，药效发生变化的药物相互作用药物，促发药物(interactiondrug,orprecipitatingdrug)在联合用药中，引起其他药物发生变化的药物 2药物相互作用的研究对象 药物在体外和药物在体内的相互作用药物...
Drug –drug interaction is a specific term for adverse effect which is used when efficacy or toxicity of one drug is modified by another drug.1Potential drug interactions can be predicted based on various properties of interacting drugs like bioavailability, mechanism of action, route of elimination...
drug–drug interactiongenotypeplatelet functionproton pump inhibitorWHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Active metabolism of clopidogrel is mainly mediated ... T Furuta,T Iwaki,K Umemura - 《British Journal of Clinical Pharmacology》 被引量: 181发表: 2010年 Drug Interaction Potential of Soy Extr...
The parent compound to metabolite ratios of warfarin, omeprazole and dextromethorphan were similar with and without administration of simeprevir, suggesting no relevant clinical interaction of simeprevir with CYP2C9, CYP2C19 and CYP2D6. Table 1 Effects of simeprevir on the pharmacokinetics (PK) of co...
There is also a growing awareness of the impact that pharmacogenomics has on drug interaction potential, resulting in interindividual variations in drug transport, metabolism and elimination. The number of potential drug interactions is extensive, but the lower incidence seen in clinical practice implies...