A misinterpretation of the importance of drug interactions has arisen because long, uncritical lists of supposed interactions have been published, but are based on animal studies, case reports, and clinical impression without confirmation of their clinical significance. Even when specific drug interactions...
This chapter concludes with a proposed clinical decision-making algorithm that may be used to ascertain the clinical significance of pharmacokinetic-mediated pharmacodynamic interactions with opioid analgesics.doi:10.1007/978-3-319-27883-4_20Tony K L Kiang...
Clinical Significance of Drug Interactions with Antirheumatic Agents Journal Clinical Immunotherapeutics Volume 5, Issue 3 , pp 205-213 Cover Date 1996-03 DOI 10.1007/BF03259083 Print ISSN 1172-7039 Online ISSN 1179-190X Publisher Springer International Publishing Additional Links Register for Journal...
Interaction mechanisms, namely inhibition and induction of UDP-glucuronosyltransferase (UGT) enzymes and the potential interplay with drug transporters, are reviewed in detail, as is the clinical significance of known DDIs. Altered victim drug exposure arising from modulation of UGT enzyme activities ...
The aim of this study was to determine whether there is consistency in the listing and clinical significance ratings of drug-drug interactions in 5 nationa... TR Fulda,RJ Valuck,JV Zanden,... - 《Current Therapeutic Research》 被引量: 159发表: 2000年 St John's wort (Hypericum perforatum)...
Potentially because of enhanced expectations for cannabidiol treatment, a higher than expected placebo effect was observed; however, this did not affect statistical significance of the treatment effect. Finally, long-term evaluation of cannabidiol in patients with TSC is needed and will be conducted in...
The American Pain Society and the College on Problems of Drug Dependence, in collaboration with the Heart Rhythm Society, commissioned an interdisciplinary expert panel to develop a clinical practice guideline on safer prescribing of methadone for treatment of opioid addiction and chronic pain. As ...
The clinical significance of propofol's long elimination half-life and low clearance is negligible when the drug is administered as short-term and low-... A Zonca,G Ravasio,M Gallo,... - 《Journal of Veterinary Pharmacology & Therapeutics》 被引量: 17发表: 2012年 加载更多来源...
Clinical significance of the sparteine/debrisoquine oxidation polymorphism The sparteine/debrisoquine oxidation polymorphism results from differences in the activity of one isozyme of cytochrome P450, the P450db1 (P450 IID1). The ... K. Brsen,LF Gram - 《European Journal of Clinical Pharmacology》...
Although lithium continues to be regarded as the treatment of choice for bipolar disorders, the clinical use of this mood stabiliser is associated with an