Drug Metabolism Letters. 2007;1:31-35.Rodriques AD. Prioritization of clinical drug interaction studies using in vitro cytochrome P450 data: proposed refinement and expansion of the `rank order'' approach. Drug Metab Lett. 2007;1:31-5.
10/24/17 Clinical Drug Interaction Studies — Study Design, Data Analysis, and Clinical Implications Guidance for Industry DRAFT GUIDANCE This guidance document is being distributed for comment purposes only. Comments and suggestions regarding this draft document should be submitted within 90 days of pu...
Clinical drug interaction studies: Cytochrome P450 enzyme- and transporter-mediated drug interactions guidance for industry. Published January 2020. Accessed June 29, 2021. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/clinical-drug-interaction-studies-cytochrome-p450-enzyme-and-...
Drugs–Drug Interaction Between Clopidogrel and the Proton Pump Inhibitors Available data suggest that omeprazole is the PPI most likely to have a significant interaction with clopidogrel. Further studies are needed to determine ... NB Norgard,KD Mathews,GC Wall - 《Annals of Pharmacotherapy》 被引...
Drug interaction studies: study design, data analysis, and implications for dosing and labeling. SM Huang,R Temple,DC Throckmorton,LJ Lesko. Clinical ... SM Huang,R Temple,DC Throckmorton,... - 《Clinical Pharmacology & Therapeutics》 被引量: 443发表: 2007年 Predicting Drug–Drug Interactions...
Clinical studies have demonstrated increases in coadministered drug concentrations for drugs that are substrates of the OATP1B1/3, BRCP (e.g. rosuvastatin) and P-gp (e.g. digoxin) transporters; these drugs should be administered with dose titration and or/close monitoring....
Drug-food interactions may result in reduced, delayed, or increased systemic drug availability. The absorption of only a small number of drugs is unaffected by concomitant food intake. The degree of interaction and whether it positively or negatively affects drug absorption depends on a number of ...
Clinical interactionvia telephone, commonly described as ‘telephone triage’ is outlined in section 3. Clinical interactionstudies with cimetidine and warfarin indicated that the coadministration of letrozole with these drugs does not result in clinically significant drug interactions, even though cimetidine...
Analysis of clinical drug-drug interaction data to predict uncharacterized interaction magnitudes between antiretroviral drugs and co-medications... F Stader,H Kinvig,M Battegay,... - 《Antimicrobial Agents & Chemotherapy》 被引量: 0发表: 2018年 Mechanism-based inactivation of human cytochrome P450 ...
The results show the tremendous variability of drug-drug interaction effects, which makes one aware of complexity of the problem, and suggests the need for assessment of an additional risk factors and careful ECG monitoring before administration of drugs with anticipated QT prolongation. DDIs can ...