[1] Q. Ren, et al., (2023). Hsk7653, a novel biweekly DPP-4 inhibitor, versus daily linagliptin as add-on therapy to metformin in Chinese patients with type 2 diabetes. https://cattendee.abstractsonline.com/meeting/10899/Session/166 免责声明:药明康德内容团队专注介绍全球生物医药健康研究进展。
所以你如果要用GLP-1和GIP,那么你必须频繁注射才有效,这样比较麻烦,于是科学家想到了一个办法,抑制DPP-4的作用。于是就有了这一类新的降糖药物,DPP-4抑制剂(DPP-4 inhibitor)。 目前已经上市的药物有: 西格列汀(Sitagliptin),商品名:捷诺维(Januvia),规格100mg/片,1片,每天一次口服; 沙格列汀 (Saxagliptin),...
4.Shi D, Chen L, Li G, et al. Clinical Pharmacokinetics. 2024 Jan. 5.LINONG JI, et al. 55-OR HSK7653, a Novel Ultralong-Acting DPP-4 Inhibitor, as Monotherapy in Patients with Type 2 Diabetes—A Randomized, Double-Blind, Placebo-Controlled Phase III Trial. ADA’s 83rd Scientific S...
A DPP-4 inhibitor containing, as an active ingredient, a peptide represented by formula (1): Xe-Pro/Ala/Hyp-Xa-Xb-Xc-Xd (wherein Xe represents an amino acid residue having an isoelectric point of 5.9-6.3; Pro/Ala/Hyp represents Pro, Ala or Hyp; Xa represents an amino acid residue ...
10. LINONG JI, FANG BIAN, TIANRONG PAN, et al. 55-OR HSK7653, a Novel Ultralong-Acting DPP-4 Inhibitor, as Monotherapy in Patients with Type 2 Diabetes—A Randomized, Double-Blind, Placebo-Controlled Phase III T...
[2]Dianna J Magliano(Co-chair),et al.IDF Diabetes Atlas.2021.[3]Linong Ji,et al.HSK7653, a Novel Ultralong-Acting DPP-4 Inhibitor, as Monotherapy in Patients With Type 2 Diabetes: a Randomized, Double-Blind, Placebo-Co...
[2]Dianna J Magliano(Co-chair),et al.IDF Diabetes Atlas.2021.[3]Linong Ji,et al.HSK7653, a Novel Ultralong-Acting DPP-4 Inhibitor, as Monotherapy in Patients With Type 2 Diabetes: a Randomized, Double-Blind, Placebo-Controlled Phase III Trial.2023ADA. ...
DPP-4 inhibitor 1 (compound 5)是有效的、长效的二肽基肽酶-4 (DPP-4) 的抑制剂,有治疗2型糖尿病的潜力,其 KD 值为0.177 nM。 在糖尿病小鼠中单剂量口服施用DPP-4抑制剂1(化合物5)(3mg / kg)抑制> 80%的DPP-4活性超过7天。 施用DPP-4抑制剂1(化合物5)(3和10mg / kg,po,qw,持续8周)导致...
[2] Fuchs H, Tillement JP, Urien S, Greischel A, Roth W. Concentration-dependentplasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356due to saturable binding to its target in plasma of mice, rats and humans. J Pharm Pharmacol. 2009;61(1):55-62....
常用名DPP-4抑制剂1英文名DPP-4 inhibitor 1 CAS号1915007-89-4分子量384.35 密度N/A沸点N/A 分子式C21H15F3N2O2熔点N/A MSDSN/A闪点N/A DPP-4抑制剂1用途 DPP-4 inhibitor 1 (compound 5)是有效的、长效的二肽基肽酶-4 (DPP-4) 的抑制剂,有治疗2型糖尿病的潜力,其 KD 值为0.177 nM。