本发明涉及一种式I所示的杂化并嘧啶酮类DPP-IV抑制剂或其盐,其制备方法,组合物及其在预防或治疗受益于DPP-IV抑制的疾病中的用途. The present invention relates to a hybrid of Formula I and pyrimidine ketones DPP-IV inhibitors or salts thereof, their preparation, compositions and their use in the ...
Alpha glucosidase inhibitor (GI) attenuates postprandial hyperglycemia (PPH) and reduces the risk of cardiovascular events in patients with impaired glucose tolerance or type 2 diabetes. Dipeptidyl peptidase 4 (DPP-4) inhibitors also attenuate PPH. PPH is one of the factors leading to endothelial dys...
DPPIV inhibitor synthesis intermediate 1 information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook.
DPP-4 inhibitor eGFR: Estimated glomerular filtration rate FDA: Food and Drug Administration GAS: Interferon-gamma-activated sequence GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 GLP-1R: GLP-1 receptor GLP-1RAs: Glucagon-like peptide-1 receptor agonists...
Changes in serum DPP-4 activity and active GLP-1 concentrations in db/+ mice and db/db mice during an oral meal tolerance test. The experiments were performed in db/+ or db/db mice fed an SL diet, an SO diet, or a diet containing the DPP-4 inhibitor 0.4 % des-fluoro-sitagliptin ...
Acute GLP-1R changes among the groups were assessed 1, 3, and 7 days with or without DPP-4 inhibitor-treated after myocardial infarction. CKD-MI model were divided into five groups (n = 6 each): control, CKD 8 weeks, CKD 8 weeks with DPP-4 inhibitor (CKD-Lina), CKD 8...
LIUY,HONGT.Combination therapy of dipeptidyl pepti-dase-4 inhibitors and metformin in type 2 diabetes:rationale and evidence[J].Diabetes Obes Metab,2014,16(2):111-117. [4] KIM HS,SHIN JA,LEE SH,et al.A comparative study of the effects of a dipeptidyl peptidase-IV inhibitor and sulfonylur...
效果。DPP-4抑制剂(如西格列汀) 发病有关。DPP-4能特异性裂解肚 者发表医学论文近300篇。 通过抑制DPP一4的活性.进而延长 链N末端第二位的脯氨酸或丙氨酸 其中scI期刊论文1 0篇;主蝙 和提高体内内源性GLP一1浓度.发 残基。DPP-4抑制剂则可通过抑匍 挥降血糖作用.目前已被用于治DPP-4的活性.延缓GLP一...
DPP IV INHIBITOR FORMULATIONS (EN)The present invention relates to a pharmaceutical formulation, characterize... A Kohlrausch,P Romer,G Seiffert - 《Seiffert Gerd》 被引量: 142发表: 2007年 Phenacyl xanthine derivatives as dpp-iv inhibitor The invention concerns substituted xanthines of general formul...
one DPP-4 inhibitor (saxagliptin) increased the risk of hospitalization for heart failure in the overall population; another (alogliptin) demonstrated inconsist... MH Secrest,JA Udell,KB Filion - 《Trends in Cardiovascular Medicine》 被引量: 8发表: 2017年 ...