Ageing is a complex process, in order to discover causative factors, a clear definition of “successful ageing” is vital. This would need to encompass the various pathways leading to exceptionally old age. In the current literature a multitude of different definitions exist, depending on the cult...
The hypoglycemic effect of berberine was similar to that of metformin—significant decreases in hemoglobin A1c (from 9.5% to 7.5%). My favorite berberine product is CM Core from Ortho Molecular. Listen to my Clinical Focus podcast episode on the subject of hemoglobin A1c. Share:...
A comprehensive literature search was performed to identify pertinent in vivo efficacy studies utilizing PP2A activators such as antineoplastic cancer drug sodium selenate [158,159,160,161]; the anti-diabetic drug, glimepiride [162] and metformin [163,164,165]; a zinc ionophore and an experimental...
Metformin, another biguanide, inhibits Complex 1 and impedes ATP production, which raises AMP levels to activate the metabolic master switch AMP kinase (Schulz et al., 2007), a target of CR and potentially at the core of life extension (Schulz et al., 2007). Notably all of these ...
It showed that between one and two-and-a-half hours of jogging per week at a “slow or average” pace delivered optimal benefits for longevity.11 4.3. Metformin A study by Bannister and co-workers revealed that patients with type 2 diabetes mellitus (DM) initiated with metformin monotherapy ...