There is growing evidence that points out to an increased life expectancy as well as quality of life in model organisms treated with metformin. Therefore, there is an abundance of research centered on elucidating the mechanism through which metformin has its anti-aging effects. Among these, the ...
Metformin is a remarkable drug that can prevent the metabolic outline of aging and influence prolonging our life span. The only common side effects seen with this drug are stomach upsets and diarrhoea. This only occurs in about 10% of users. It is also recommended that patients should start t...
The diabetes mellitus drug metformin is under investigation in cardiovascular disease, but the molecular mechanisms underlying possible benefits are poorly understood.Here, we have studied anti-inflammatory effects of the drug and their relationship to antihyperglycemic properties.In primary hepatocytes from ...
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects? Here we propose that SGLT2 inhibitors (SGLT2i), a class of drugs primarily used to treat type 2 diabetes, could also be repositioned as anti-aging senomorp... L Scisciola,F Olivieri,C Ambrosino,......
metformin. Therefore, there is a need for large-scale, multicenter, randomized, placebo-controlled trials to further elucidate the anti-aging effects of metformin. Recommendations to treat older adults with metformin may require a personalized, precise approach. Once we have better biomarkers of the ...
Aging is a complex and multifaceted process involving a variety of interrelated molecular mechanisms and cellular systems. Phenotypically, the biological aging process is accompanied by a gradual loss of cellular function and the systemic deterioration o
found no benefit for disease-free survival or overall survival with metformin. This major failure of observational real-world evidence studies in correctly assessing the effects of metformin on cancer incidence and outcomes was caused by preventable biases which, surprisingly, are still prominent in 202...
Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus. The biguanide metformin (dimethylbiguanide) is an oral antihyperglycaemic agent used in the management of non-insulin-dependent diabetes mellitus (NIDDM). ......
Cites the development of an anti-aging therapy by BioMarker Pharmaceuticals. Discovery of a drug used for the treatment of diabetes called metformin; Mimicry of changes in gene expression found in calorically-restricted mice; Description of caloric restriction as a method of slowing down aging. INSE...
Anti-Aging Effects of Young Blood In biology, parabiosis is the joining of two animals’ circulatory systems. Historically it was noticed that connected healthy animals could extend the lifespan of treated animals [65], although such effects have not been subsequently validated. In a series of st...