Neurocognitive effects independently associated with type 2 diabetes and age were examined in 20,314 individuals from the UK Biobank. A separate meta-analysis evaluated 34 published cognitive studies (N = 22,231) and 60 neuroimaging studies, 30 of type 2 diabetes (N = 866) and 30 of aging (...
Skin agingMetformin has shown multiple effects beyond its widely known antidiabetic effect. Impressively, it has already been proposed as an anti-aging factor. However, the potentially protective role of metformin in skin aging, the most common manifestation of aging, is not well examined. Existing...
Furthermore, the factors that influence extreme longevity have received different amounts of attention, with some influential factors having been omitted. One of the neglected areas could be the importance of oral health in achieving very old age. The following narrative review will illustrate the cu...
Many of these drugs can turn out to be very affordable, too. Metformin costs just 5 cents per pill, and that’s cheaper than almost any prescription drug out there. This plays in wonderfully to Americans health concerns, as they may eventually be able to maximize their healthy years. ...
Similar results are found in mice with fructose-induced steatosis: treatment with metformin leads to a decrease in hepatic triglyceride accumulation and plasma alanine-aminotransferase levels and protection against the loss of the TJ proteins occludin and ZO-1 in the duodenum[176]. In humans, an ...
In a small pilot study, a group of patients with Type 2 diabetes were given berberine (500 mg three times daily) or the medication metformin for 3 months. The hypoglycemic effect of berberine was similar to that of metformin—significant decreases in hemoglobin A1c (from 9.5% to 7.5%). My...
The findings, published in the current issue ofResearch on Aging, suggest that after age 70, educated adults may begin to lose the ability to use their schooling to compensate for normal, age-related memory loss. Study director Eileen Crimmins of the USC Leonard Davis School of Gerontology say...
NLRP3 inflammasome drives inflammation in high fructose fed diabetic rat liver: effect of resveratrol and metformin Life Sci., 253 (2020), 10.1016/j.lfs.2020.117727 Google Scholar Rebelos et al., 2021 E. Rebelos, J.O. Rinne, P. Nuutila, L.L. Ekblad Brain glucose metabolism in health,...
A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched non-diabetic controls Diabetes Obes Metab, 16 (2014), pp. 1165-1173 CrossrefView in ScopusGoogle Scholar 13 M.V. Blagosklonny Prospective treatment of age-related diseases by slowing down aging...
Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a. J. Cachexia Sarcopenia Muscle 2022, 13, 605–620. [Google Scholar] [CrossRef] Pasteuning-Vuhman, S.; Boertje-van der Meulen, J.W.; van Putten, M.; Overzier, M.; Ten Dijke, P.; ...