This article reviews the effects and the underlying mechanisms of metformin on the biological properties, including proliferation, multi-differentiation, and aging, of MSCs in vitro and in vivo with the aim of providing theoretical support for in-depth scientific research and clin...
The researchers state that this could, at least in part, be due to metformin’s effects on blood sugar: “The beneficial effects of metformin on aging could involve HbA1c lowering via GPD1 and AMPKγ2 targets, indicating that the glycemic property of metformin could be one of its mechanistic...
One of the most widely used medications in the world, metformin is commonly prescribed for Type 2 diabetes. However, in addition to its effects on lowering blood sugar, in preclinical models, metformin shows benefits on aging and a number of diverse diseases such as cognitive disorders, cancer,...
While the longevity benefits of metformin are promising, it appears that the effects are only to be enjoyed by animals or people living with diabetes. So, is it really the key to healthy aging or is it simply an effective diabetes drug? To answer this question, the FDA approved a study ...
[12] Owen, M. R., Doran, E., & Halestrap, A. P. (2000). Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. The Biochemical journal, 348 Pt 3(Pt 3), 607–614. ...
Use of metformin in diseases of aging. Curr Diab Rep. 2014 Jun;14(6):490. 16. Lin HC, Stein JD, Nan B, Childers D, Newman-Casey PA, Thompson DA, Richards JE. Association of Geroprotective Effects of Metformin and Risk of Open-Angle Glaucoma in Persons With Diabetes Mellitus. JAMA ...
Metformin is a remarkable drug that can prevent the metabolic outline of aging and influence prolonging our life span. The only common side effects seen with this drug are stomach upsets and diarrhoea. This only occurs in about 10% of users. It is also recommended that patients should start ...
We calculated total, natural direct, and natural indirect effects of metformin termination on time to dementia and 95% CIs. The following sensitivity analyses were performed: First, we repeated analyses using creatinine instead of eGFR. Gender-specific cutoffs of 1.4 mg/dL (124 μmol/L) or ...
Metformin has been shown to have various beneficial effects on health, such as lowering blood sugar levels, reducing the risk of cancer development, and slowing down the aging process. However, the immunomodulatory effects of metformin on senescent T cells still need to be investigated. Methods ...
This chapter details what these data suggest about metformin's potential influence on diseases of aging and life span if employed as a geroprotective agent in the general population, causes for caution in its potential roles, and the molecular pathways of its effects. View chapter Book 2023, ...