Type 2 diabetes appears to markedly accelerate normal brain aging. Metforminuse does not appear to prevent neurocognitive decline. Why This Matters Although preliminary evidence links type 2 diabetes to neurologic and cognitive decline, patients don't typically undergo comprehensive neurocognitive evaluation ...
MetforminPhotoagingSkin agingMetformin has shown multiple effects beyond its widely known antidiabetic effect. Impressively, it has already been proposed as an anti-aging factor. However, the potentially protective role of metformin in skin aging, the most common manifestation of aging, is not well ...
Ageing is a complex process, in order to discover causative factors, a clear definition of “successful ageing” is vital. This would need to encompass the various pathways leading to exceptionally old age. In the current literature a multitude of different definitions exist, depending on the cult...
The findings, published in the current issue ofResearch on Aging, suggest that after age 70, educated adults may begin to lose the ability to use their schooling to compensate for normal, age-related memory loss. Study director Eileen Crimmins of the USC Leonard Davis School of Gerontology say...
In a small pilot study, a group of patients with Type 2 diabetes were given berberine (500 mg three times daily) or the medication metformin for 3 months. The hypoglycemic effect of berberine was similar to that of metformin—significant decreases in hemoglobin A1c (from 9.5% to 7.5%). My...
Similar results are found in mice with fructose-induced steatosis: treatment with metformin leads to a decrease in hepatic triglyceride accumulation and plasma alanine-aminotransferase levels and protection against the loss of the TJ proteins occludin and ZO-1 in the duodenum[176]. In humans, an ...
NLRP3 inflammasome drives inflammation in high fructose fed diabetic rat liver: effect of resveratrol and metformin Life Sci., 253 (2020), 10.1016/j.lfs.2020.117727 Google Scholar Rebelos et al., 2021 E. Rebelos, J.O. Rinne, P. Nuutila, L.L. Ekblad Brain glucose metabolism in health,...
This brings out an interesting prospect of metformin as first-line therapy and may imply that metformin may confer benefit even in non-DM.12 4.4. Geroprotectors Experimental proof of this class of drugs comes from sirolimus. It is an immune-modulator (also the drug in drug-eluting stent) ...
Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue. Cell. Signal. 2016, 28, 1401–1411. [CrossRef] [PubMed] 59. Bariani, M.V.; Correa, F.; Leishman, E.; Domínguez Rubio, A.P.; Arias, A.; Stern, A.; ...