Radiation therapy halts the cell cycle. This is because the energy imparted by radiation damages the DNA of a cell. This damage causes the cell to be...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your ...
Osteoarthritis (OA) is a degenerative multifactorial disease with concomitant structural, inflammatory, and metabolic changes that fluctuate in a temporal and patient-specific manner. This complexity has contributed to refractory responses to various tre
To stringently probe the clinical efficacy of MSC therapies from a larger collection of reported data, we collected published data on RCTs for MSC effects in OA. We reviewed clinical trials from the PubMed database using the following search string: “mesenchymal stromal cell” or “mesenchymal ...
29,30]. Sequential hermaphroditism, in which individuals change sex as a normal part of their life history, is widespread among fishes. Typically, protogynous sex change from female to male in fishes involves
Yes, cell therapy of rheumatic diseases needs new concepts to become a true alternative to conventional therapies. Although still a vision, the combination of targeted deletion of autoreactive cells, identified according to their specificity, with the therapeutic resetting of peripheral and central toler...
Evenness can also be applied to T-cell therapy by providing manufacturing quality control information on engineered T cells in production. In adoptive cell therapy (ACT), a patient’s own T cells are genetically modified to target antigens selectively expressed on c...
A novel allergen-specific therapy for allergy using CD40-silenced dendritic cells J. Allergy Clin. Immunol., 125 (2010), p. 743 e1 Google Scholar Svensson et al., 1997 M. Svensson, B. Stockinger, M.J. Wick Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II ...
These molecules mediate an inflammatory response through cell activation to induce, for example, chemotaxis and histamine release. Rights and permissions Reprints and permissions About this article Cite this article Schwab, I., Nimmerjahn, F. Intravenous immunoglobulin therapy: how does IgG modulate the...
the interaction with macrophages and dendritic cells an increased production of cytokines, e.g. Interleukin 1 (IL1), Interleukin 6 (IL6) and tumor necrosis factor alpha (TNF ⍺) occurs. Furthermore, proinflammatory cytokines promote chemotaxis, increasing immune cell recruitment and aggravating the...
Previous work reported that patients with CHIP prior to autologous stem cell transplantation (ASCT) had adverse survival after ASCT compared to those without CHIP.27 The same study demonstrated an increased risk of therapy-related myeloid neoplasm (TMN) in patients carrying CHIP. In addition, an in...