doi:10.1111/j.1365-2141.2006.06197.xHuw RoddieDepartment of Haematology, Western General Hospital, Edinburgh, UK. E‐mail: huw.roddie@luht.scot.nhs.ukJohn Wiley & Sons, LtdBritish Journal of Haematology
Interdisciplinary Critique of Sipuleucel-T as Immunotherapy in Castration-Resistant Prostate Cancer: Huber ML, Haynes L, Parker C, etal (Trudeau Inst, Saranac Lake, NY; The Royal Marsden NHS Foundation Trust, UK) J Natl Cancer Inst 104:2... Advances in our basic understanding of the pathophys...
Mouse monoclonal anti-human antibodies, diluted in 10% normal horse serum (NHS), were used at the following concentrations, CD1a at 1/500 (Dako, Denmark), CMRF 44 and CMRF 56 both at 1/50 (D Hart, New Zealand), mouse isotype negative control 2 μg ml−1 (Zymed, CA, USA)...
differentiation (Fig.5e). Immunofluorescence analysis further supported this observation and demonstrated the existence of cell-to-cell contact between MS5_FS12 and human CD45+leukocytes (Fig.5eand Supplementary Fig.5a). Leukocytes expressing CD34+could also be detected, supporting the notion that a ...
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. Funding for A.N. and S.C.K. was from London North West University Healthcare NHS Trust R&D. L.H. was in receipt of an MRC Intermediate Research Fellowship (grant number MR/L01632X/1, UK Med-Bio). Author information Author notes Régis Stentz and Alistair Noble contributed equally ...
Mucosal viral infection induces a regulatory T cell activation phenotype distinct from tissue residency in mouse and human tissues Article11 July 2022 Introduction There is still no cure or vaccine for HIV/AIDS and 37 million people remain infected. Antiretroviral therapy (ART) is efficient at contro...
Clonal haematopoiesis (CH) refers broadly to the presence of a population of cells derived from a mutated multipotent stem/progenitor cell harbouring a selective growth advantage in the absence of unexplained cytopenias, haematological cancers, or other clonal disorders. The incidence of CH increases ...
Materials Hyaluronic acid (HA, MW = 4.8 kDa), 3-(diethylamino)propylamine (DEAP), N-hydroxysuccinimide (NHS), N,N -dicyclohexylcarbodiimide (DCC), triethylamine (TEA), deoxycholic acid (DOCA), 4-dimethylaminopyridine (DMAP), pyridine, dimethyl sulfoxide (DMSO), sodium tetraborate (Na2B4O7),...
The majority of tumor-associated DCs (TADCs) in colon cancer have been shown to display an immature state, with a substantial subset expressing high levels of inflammatory cytokines/chemokines or the T-cell inhibition ligand PD-L1 [12,13]. Communication between colon cancer cells and DCs is ...