Ethics approval was obtained from the Health Research Authority UK and London Brent Research Ethics Committee. Written informed consent was received from participants prior to inclusion in the study. For whole biopsy culture experiments, healthy donors were recruited from endoscopy clinics at Norfolk and...
Development and Recent Advances CAR T Cell Therapy 2.1.1. Haematological Cancers CAR T cell therapy utilises T cells harvested from cancer patients (apheresis) which are subsequently antibody activated and transduced with either a lentivirus or retrovirus vector. Cells expressing the synthetic CAR are...
In contrast to labor-intensive autologous cell transfer approaches, direct targeting of DCs in vivo is not regularly employed in the clinics, even though this could allow for harnessing specialized DC subsets in their natural environment. 6.2. Antigen Targeting Enables the Induction of Antigen ...