树突状细胞(Dendritic cells) 简介 树突状细胞( DC )是哺乳动物免疫系统中的抗原呈递细胞(也称为辅助细胞)。DC 的主要功能是处理抗原物质并将其呈递到细胞表面,供免疫系统的T 细胞使用。它们充当先天免疫系统和适应性免疫系统之间的信使。树突状细胞存在于与身体外部环境接触的组织中,例如皮肤(其中有一种特殊的树突...
Striking a balance: new perspectives on homeostatic dendritic cell maturation Dendritic cells (DCs) act as gatekeepers between immunity and tolerance. Initially, it was postulated that mature DCs promote effector T cell responses and immature DCs promote tolerance. Recent studies have shown instead that...
Dendritic cell maturation in cancer Dendritic cells (DCs) shape the adaptive immune response to peripheral tissue antigens and, as such, are crucial for mounting an effective antitumour immune response in cancer. This Review outlines the molecular basis of DC maturation, highlights the mechanisms thr...
To increase our understanding of dendritic cell (DC) function we have used two approaches to search at the genetic level for molecules which are specifically expressed by these cells. First, we have performed random sequencing of cDNA libraries prepared from DC. Second, we have employed differentia...
Dendritic cells (DC), professional antigen-presenting cells of the immune system, exert important functions both in induction of T cell immunity, as well a... N Cools,P Ponsaerts,VFIV Tendeloo,... - 《J Leukoc Biol》 被引量: 1087发表: 2007年 IL-6 controls Th17 immunity in vivo by in...
at high levels on the surface of bone marrow-derived DCs and at lower levels on macrophages. DC-HIL acts as a negative regulator ofT cell activationwhere its putative ligand is expressed on activated but not on resting T cells (Figure 11.2). The binding of DC-HIL to its ligand potentially...
3.2Follicular dendritic cells Follicular dendritic cells(FDCs) arestromal cellslocated in the B-cell rich follicles of secondarylymphoid organs[48]. These cells originate from vascular mural cells and require LT andTNFfor development but only LT for maintenance[49,50]. These signals are provided pr...
DC树突状细胞树突状细胞(dendritic cells, DC)广泛分布于脑以外的全身组织和脏器,数量较少,仅占人外周血单个核细胞的1%,因其具有许多分枝状突起故名。 树突细胞是已知体内功能强大、能活化静息T细胞的专职抗…
Immunofluorescence microscopy confirmed CD11c positivity on the gfp + donor cells, which localized in T-cell zones of mesenteric lymph nodes, Peyer's patches, spleen, and thymus. These findings are important for adoptive immunotherapies because they indicate that eDCs migrate efficiently in vivo and ...
Anti-IL-1Ra neutralizing antibodies or RPE cells from IL-1Ra knockout donors were used for the assay.Cultured RPE cells greatly suppressed the activation of mDCs, especially the production of pro-inflammatory cytokines, and the expression of cell-surface molecules. Moreover, RPE cells significantly...