ProteinCell countPathological CSF values such as WBC count and persistently elevated protein level serves as a risk factor for early valve obstruction. Late obstruction occurs independent of normal CSF values. Infants are particularly prone to early and late valve obstructions. CSF protein level at ...
It has been shown that Aβ derived from amyloid-containing brain tissue has prion-like properties: it induces misfolding and aggregation of Aβ when injected into human amyloid precursor protein (APP) transgenic mice. In contrast, Aβ in the CSF has been less studied, and it is not clear ...
Protein kinases (PKs) have emerged as one of the most intensively investigated drug targets in current pharmacological research, with indications ranging from oncology to neurodegeneration. Tau protein hyperphosphorylation was the first pathological post-translational modification of tau protein described in A...
As there is currently no evidence that CSF and ECF concentrations of PPs exceed 1–5 micromolar (at best), it is thus highly unlikely that intracellular PP concentrations in neurons and glial cells will exceed the very low micromolar to nano- molar range. This, clearly, is not sufficient ...
more cerebrospinal fluid (CSF) to flow in and out. That’s the liquid that surrounds your brain and spinal cord. Compared to when you’re awake, CSF helps clear out more waste that can hurt your cells. Deep sleep also gets rid of beta-amyloid, a protein linked to Alzheimer’s disease...
The actions of orexins are mediated via two G protein-coupled receptors, orexin receptor 1 and orexin receptor 2. Orexin receptor 1 shows a greater affinity for orexin A, whereas orexin receptor 2 is a non-selective receptor for both orexin A and orexin B. Cells in the TMN zone have ...
The few studies analyzing antemortem cerebrospinal fluid (CSF) with known underlying neuropathology have revealed several candidate biomarkers (e.g., p/tTau ratio) [2,3,4]. However, their specificity is still not optimal and most of the identified markers are awaiting further validation [2]. ...
EnglishEspañolDeutschFrançaisItalianoالعربية中文简体PolskiPortuguêsNederlandsNorskΕλληνικήРусскийTürkçeאנגלית 9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook ...
As there has been a single report of decreased CSF LCAT activity in human AD subjects (42), we first determined whether age and/or the presence of Aβ deposits impacts LCAT expression or activity in APP/PS1 mice. As amyloid deposition and behavioral deficits have been reported to start betwe...
The enzyme amount in CSF, as measured by densitometry of the protein band revealed by immunoblotting, was about 4-fold higher in patients than in controls (p=0.0085). As differences in the concentration of the LCAT stimulator Apolipoprotein E were not found, we hypothesized that the reduced ...