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CSF Protein Level of Neurotransmitter Secretion, Synaptic Plasticity, and Autophagy in PD and DLBlysosomesecretionsynaptic plasticityCSFPDGBABackground Molecular pathways associated with α‐synuclein proteostasis have been detected in genetic studies and in cell models and include autophagy, ubiquitin‐...
CSF NfL level increase is correlated with histopathological phenotype in HD. (A,B) Stereological assessments of (A) dorsal striatum volume and (B) medial corpus callosum thickness showed a pathological reduction in brain matter in R6/2 compared to WT mice. (C) Cresyl violet staining of represen...
Using real-time PCR, we determined the ABCA1 mRNA level in macrophages cultured for 5 days with macrophage colony-stimulating factor (M-CSF). The ABCA1 mRNA level in macrophages from patients with arterial stenosis was increased compared to the control group, p = 0.04. Western-blot assayed ...
The presence of such markers in CSF after brain damage is transient and it is essential to understand their kinetics if they are to be used in clinical practice. In the present study, the CSF concentrations of two neurospecific proteins, S-100 protein and neuron-specific enolase (NSE), were...
In addition to rareSNCAmultiplication (Johnson et al., 2004) underlying transcriptional dysregulation in PD, common variation in the promoter region ofSNCAhas also been shown to influence α-synuclein expression level. Rep1, a polymorphic dinucleotide repeat element about 9kb upstream of the transcrip...
Cerebrospinal fluid C-reactive protein (CSF-CRP) was studied in 183 consecutive infants and children with suspected meningitis, using a nephelometric technique. Cerebrospinal fluid C-reactive protein was above an empirically chosen level of 1mg/1 in seven of 19 children with culture-proven bacterial ...
(Sanna et al., 2000). An increased level of GFAP in the CSF of patients with NPSLE was recently observed (Trysberg et al., 2003). Moreover, successful therapy with cyclophosphamide in NPSLE patients resulted in significantly decreased CSF levels of GFAP. On the contrary, other Authors ...
(Table1). These results indicated that the production of PLA2in the 12-copy strain was much higher than that in the 1-copy strain. However, after normalizing the data by copy number we found that the normalized PLA2protein concentration, enzyme activity and the transcription level in MC ...
protein, mRNA, and BACE1 activity in the cerebrospinal fluid (CSF) have been reported to be increased in studies of AD6,7,8,9. Additionally, utilizing ELISAs that measure the absolute concentrations of analytes, we previously demonstrated that there is an increase in the ratio of sAPPβ/sAPP...