An interesting addition to administration of stem cell activators is the localized introduction of stem cell specific chemoattractant agents at the site in need of repair, followed by systemic administration of cord blood stem cells. Chemoattractant agents could include stromal derived growth factor-1 [...
Gcn5 was rapidly shown to function as a subunit of the Spt-Ada-Gcn5-acetyltransferase (SAGA) complex, which is a paradigmatic example of such multifunctional co-activators. We now know that Gcn5 is the catalytic component of multiple co-activator complexes with distinct functions. In this ...
This apoptotic cell death can occur by inducing an up regulation of pro-apoptotic proteins or by directly decreasing the anti-apoptotic reservoir to allow the activators to initiate MOMP. Most anti-cancer agents like targeted therapies, DNA-damaging agents, microtubule inhibitors or other cytotoxic ...
3 Figure 1 Screening of a library of 100 plant extracts for Wnt/β-catenin pathway activators. HEK293-reporter cells were treated with extracts for 24 h, and cell lysates were subjected to TOPflash reporter assay (n = 3). (a) A library of 100 plant extracts was screened. (b) HEK293...
The roles of TGFbeta Glioblastoma cancer-initiating cells inhibit T-cell pro- in the tumor microenvironment. Nat Rev Cancer. liferation and effector responses by the signal trans- 2013;13(11):788–99. https://doi.org/10.1038/ ducers and activators of transcription 3 pathway. Mol nrc3603. ...
Plant Cell 19:2776–2791 CAS PubMed PubMed Central Google Scholar Zhou J, Lee C, Zhong R, Ye ZH (2009) MYB58 and MYB63 are transcriptional activators of the lignin biosynthetic pathway during secondary cell wall formation in Arabidopsis. Plant Cell 21:248–266 CAS PubMed PubMed Central...
The interaction between NICD and CSL is followed by the assembly of co-activators to induce transcription, and the pathway itself is in fact modulated by a number of interacting factors (Andersson et al., 2011, Bray, 2016). Download: Download high-res image (935KB) Download: Download full-...
It will also be interesting to see whether DUB activators exist that complement the catalytic triad in an analogous manner as that observed in OTULIN. Ub-mediated substrate-assisted catalysis was recently shown to be crucial for the assembly of Lys11-linked polyUb, where Ub Glu34 complements ...
Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. Cancer Res 2007; 67: 8828–8838. CAS PubMed Google Scholar Bae KM, Wang H, Jiang G, Chen MG, Lu L, ...
Aziz MH, Manoharan HT, Church DR, Dreckschmidt NE, Zhong W, Oberley TDet al. Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.Cancer Res2007;67: 8828–8838...