Cell Stem Cell 22, 252–261.e254 (2018). Article CAS PubMed Google Scholar Weltner, J. et al. Human pluripotent reprogramming with CRISPR activators. Nat. Commun. 9, 2643 (2018). Article PubMed PubMed Central CAS Google Scholar Mahata, B. et al. Compact engineered human ...
Sirtuin activators and inhibitors: Promises, achievements, and challenges. Pharmacol. Ther. 188, 140–154 (2018). CAS PubMed PubMed Central Google Scholar Horvath, S. & Raj, K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat. Rev. Genet. 19, 371–384 (...
The development of the central nervous system in vivo is governed by a tightly regulated balance between neural stem/progenitor/precursor cell (NPC) proliferation and differentiation towards mature cell types (reviewed in [1,2]). During early embryonic development in vivo (for details on the concep...
most efforts have focused on using autophagy inhibitors in tumour cell lines with high levels of basal autophagy (such as those with oncogenic RAS mutations) or on using autophagy inhibitors in conjunction with agents that directly stimulate autophagy signalling pathways (such as mTOR ...
Kinase Degraders, Activators, and Inhibitors: Highlights and Synthesis Routes to the Chemical Probes on opnMe.com, Part 1ChemMedChem 2023, 18, No. 10, e202300031 Merve Camci, Nilgün KaraliBioisosterism: 1,2,4-Oxadiazole RingsChemMedChem 2023, 18, No. 9, e202200638 Jansi Rani J, Sovan...
Mediator serves as a functional bridge between specific transcription factors, DNA-bound transcriptional activators or repressors and the transcriptional machinery required for the initiation of transcription by the basal transcriptional machinery (including RNA polymerase II and general transcription factors)....
Activation of signal transducers and activators of transcription 3 and focal adhesion kinase by stromal cell-derived factor 1 is required for migration of human mesenchymal stem cells in response to tumor cell-conditioned medium. Stem Cells 27, 857–865 (2009). CAS PubMed Google Scholar Spaeth,...
In the functional, non-thrombogenic vascular endothelium, ECs secrete mediators such as nitric oxide, prostacyclin, urokinase, tissue-plasminogen activators, and heparin-like compounds [26], thereby inhibiting vessel-wall-injury-induced proliferation and migration of SMCs and consequently preventing NIH [...
progenitor cells (HSPCs) [33,34]. A work by Filion et al. showed that in human embryonic stem cells (HES) subjected to ionizing radiation the expression of this IAP along with checkpoint kinase 2 (Chk2) helps to recuperate DNA damage without the dependency on p21 to support cell cycle ...
Cell Chem. Biol. 26, 1180–1186 (2019). Article CAS PubMed PubMed Central Google Scholar Thakur, C. S. et al. Small-molecule activators of RNase L with broad-spectrum antiviral activity. Proc. Natl Acad. Sci. USA 104, 9585–9590 (2007). Article CAS PubMed PubMed Central Google ...