ATM are known to be the most abundant immune cells in the adipose tissues of obese individuals26. While they comprise fewer than 10% of the total immune cells in lean adipose tissues, this fraction rises to more than 50% in obese adipose tissues26. Furthermore, the number of ATM has been...
Nat. Cell Biol., 10 (2008), pp. 707-715 CrossrefView in ScopusGoogle Scholar [33] Z. Nagy, L. Tora Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation Oncogene, 26 (2007), pp. 5341-5357 CrossrefView ...
Results : The use of PRP for the treatment of AGA has received considerable attention, but the lack of standard protocols (various centrifugation methods, platelet concentrations obtained, whether or not activators are added, etc.) has resulted in conflicting clinical outcomes. Several studies using ...
While the physiology of each of these states differs considerably, each is referred to as 'cell cycle arrest' or 'G1 arrest'. Scope: Here the physiology and molecular regulation of (1) meristematic quiescence, (2) dormancy and (3) terminal differentiation (cell cycle exit) are considered in...
What effect do transcription factors have on a cell's proteome? Define transcription factor. What are the main differences between translation and transcription? What role do activators, transcription factors, and the mediator play in transcription? What are the major dif...
These consist of two copies each of histones H2A, H2B, H3 and H4 that are wrapped by 147 bp of DNA, which passes 1.67 times around the histone octamer. Bivalent chromatin Bivalent chromatin contains histone modifications that are catalysed by both activators (trimethylated Lys4 of histone 3 (...
The mechanisms involved in radiation recall pneumonitis are still being investigated. However, postulated theories include: (1) constant subliminal inflammatory cytokine secretion; (2) changes in local stem cell function, either increased turnover (which increases their susceptibility to antineoplastic ...
restoring NAD⁺ levels has emerged as a therapeutic approach to prevent and treat aging-related diseases and to restore health and vigor during the aging process. Some potential strategies that boost NAD⁺ levels include lifestyle changes, the use of small-molecule inhibitors or activators to bo...
Given that cell size is important, how can a cell control how big it is? In terms of 'design principles' for a size control system, the most fundamental question is whether cells need to know how big they are in order to regulate size. The simplest model is one in which cell mass gr...
new therapeutic approaches to treating disease in animal models, some of which are beginning to be seen in the first human clinical trials. We discuss the direct application of these techniques to rheumatic diseases, which are currently limited but are sure to increase rapidly in the near future...