IL-2 stimulation of fetal day 18 murine thymocytes results in a cell population of which 45% of the cells express the TcR Vγ3 [2]. In this study, we describe that those IL-2 cultured TcR Vγ3 + thymocytes have the killing capacity of lymphokine activated killer cells: NK-susceptible...
体外研究 Dostarlimab(10-10000 ng/mL)以剂量依赖的方式与人和食蟹猴CD3+T细胞上表达的原生PD-1受体结合。 Dostarlimab(0-375 nM;48 h)在人CD4+T细胞MLR实验中增加IL-2的产生,EC50大约为1 nM,在葡萄球菌肠毒素B(SEB)刺激的PBMC细胞中增加IL-2的产生,EC50大约为0.1 nM,增强干扰素(IFN)-γ的释放,EC50大...
www.nature.com/scientificreports OPEN Preceding Viral Infections Do Not Imprint Long-Term Changes in Regulatory T Cell Function Felix Rost1, Katharina Lambert1,2, Nikolas Rakebrandt1,3 & Nicole Joller1 ✉ Regulatory T cells (Tregs) maintain peripheral self-tolerance and limit immune ...
The activation of OSCAR by the collagen sequence triggers the nuclear factor of activated T-cells (NFAT), which signals via the CD3ζ cytoplasmic signaling domain [196]. During wound healing, collagen fragments activate with the GPVI receptor in coagulation, and the activated GPVI initiates the ...
4.1. Humanized Mouse Models with Functional Human Immune Cells, Lymphoid Organs, and Immunity Significant progresses have been made in the past 10 years after the generation of several immunodeficient mice that lack NK cells as well as T and B cells. Both BalbC rag-γC-null (DKO) and Nod-...
自然杀伤性细胞(NK 细胞)是人体外周血的淋巴 细胞,其特征性的表面分子是 CD56 和 CD16,不表达 CD3,具有很强的抗肿瘤和抗病毒的能力[9].因其能够 识别 MHC-I 类分子缺失的肿瘤细胞,不依赖于 MHC 分 子的限制性,并且其杀伤肿瘤效率高等特点,NK 细胞常 被用于肿瘤免疫治疗[9].NK 细胞的功能受到其表面的 ...
5. The development, activation, function and mechanisms of regulatory alpha-beta-TCR+CD3+CD4-CD8-NK- T cells in the suppression of allogeneic and autologous immune responses. [D] . Ford, Megan S. 2007 机译:调节性α-β-TCR+ CD3 + CD4-CD8-NK-T细胞在同种异体和自体免疫反应抑制中的发展...
皮肤肿物免疫组织化学检查结果:CD2、CD3、CD5均阳性,CD4弱阳性,CD8、CD30、T细胞细胞内抗原-1(T cells inner antigen-1, TIA-1)、粒酶B(granzyme B, GrB)均阴性,细胞增殖核抗原Ki-67(75%阳性),诊断:原发性皮肤T细胞淋巴瘤-非特指型(primary cutaneous T-cell lymphoma-unspecified, PCTCL-U)。 图1 原发...
人类NK细胞的分化抗原很多,其中具有代表性的细胞表型为CD3一、CD56+、CDl6q7’射。人外周血约80-90%的NK细胞低密度表达CD56(CD56m。),同时高水平表达CDl6(CDl6啪曲),可有效地发挥细胞毒作用;约10—20%的NK细胞表型为CD56brishCDl6以。或CD56M曲CDl6一,其功能主要是分泌细胞因子,参与机体的免疫调节。但在...
Some human NKT cells express an extremely restricted T-cell receptor (TCR) repertoire, including an invariant V[alpha]24 chain preferentially paired with a V[beta]11 chain, together with an NK cell receptor (NKR-P1A) (3-7). NKT cells specific...