Donor regulatory T cells (CD3+ alphabetaT-cell receptor [TCR]+) derived from the repopulating host thymus have been shown to be primarily responsible for suppression of GVHD following DLI therapy in murine BMT models. However, natural killer (NK) T cells also have regulatory properties, and a...
14 Afeta todas as populações de linfócitos: células T citotóxicas e T auxiliares, células B e células NK e sua extensão depende da magnitude do trauma cirúrgico. Em nosso estudo, uma redução significativa do número de células T CD3/4 e T CD3/8 circulantes foi ...
Through direct cytotoxicity or by the secretion of cytokines, NK cells also prevent overproliferation of precursor cell populations, thereby exerting a more discriminating control over antigen-specific T and B cell responses. The ultimate refinement of the killer cell is the cytotoxic T cell which ...
Type 1 interferons (IFN-α/β) have recently been shown to inhibit interleukin-7 (IL-7)-induced growth and survival of early B-lineage cells. The CD3− CD4− CD8− (triple negative; TN) thymocytes from normal mice strongly proliferated upon stimulation with IL-7 in suspension culture....
Objective: The three main types of killer cells – CD8+ T cells, NK cells and NKT cells – have been linked to asthma and chronic obstructive pulmonary disease (COPD). However, their role in a small subset of asthma patients displaying fixed airway obstruction (FAO), similar to that seen ...
Heat map display of murine ABC transporter normalized expression level in five highly purified immunocyte populations based upon ImmGen Deep RNA-seq data [151] (GEO accession: GSE122597), namely NK Cells, Follicular B, Naive CD4+, αβT, γδT cells, and peritoneal macrophages Full size image...
Several investigators have shown that T cells readily secrete GM-CSF (200-7000 pg/mL) upon stimulation with anti-CD3 70, 71, 72; its direct effect on T cells remains elusive, however. Since the β chain of the GM-CSF receptor is not expressed by most resting T cells, it is likely ...
Term decidual cells were most commonly positive for CD16 (neutrophils) with fewer tissues containing CD56ϩ (NK cells), CD14 (monocyte/macrophage lineage), or CD3ϩ cells (T- lymphocytes). This distribution reflects previous data on leu- kocytes in term decidua (37). Few term tissues ...
Both combinations also induced similar CD3-stimulated peripheral blood mononuclear cell- and NK-cell mediated killing of MM cells in a coculture model. The levels of multiple signaling molecules and activation markers on the surface of T and NK-cell subsets demonstrated that a 100-fold lower ...
CD3AK (anti-CD3 antibody induced activated killer) cells and cytotoxicity to colon cancer cell line, especially at a dose of 0.15 µmol/l. A recent in vitro study demonstrated promising effects of α-thujone against glioblastoma cells whose viability and invasive potential were decreasing. In a...