The cannabinoids exert their activity via two G protein-coupled receptors (CB1 and CB2) which are present throughout the brain but also seen in B and T lymphocytes, macrophages, spleen, tonsils, and lymph nodes. MCL cells have previously been shown using gene expression profiling to express ...
Harris NL, Hasserjian RP, Zukerberg LR, Abramson JS, Hochberg EP, Lee H, Lee AI, Toomey CE, Sohani AR (2010) B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell...
Figure 5. Immunohistochemistry for CD45 (leukocyte common antigen; a and b), CD14 (monocytes and macrophages; c and d), CD16 (neutrophils; e and f), CD56 (natural killer cells; g and h), CD3 (T-lymphocytes; i), and control antibody (j). Tissues are from term (a, c, e, g, ...
(MSS)呈正相关,而脾 CD3+ CD4+细胞上 PD⁃1 的表达与 MSS 呈负相关.用日本血吸虫可溶性虫卵抗原 (SEA)和可溶性雄虫抗原(SMWA)免疫小鼠后观察到,SEA 免 疫后,脾脏 T 细胞上 PD⁃1 的表达高于 SMWA 免疫,且主要使 DCs 表面的 PD⁃L2 表达上调;SMWA 免疫后,主要表现为 T 细 胞上 PD⁃L1 ...
用 于抑制PI3K活性的抑制剂wortmannin购自美国 MedChemExpress公司.所用一抗为鼠抗,分 别为抗Nrf2,抗pNrf2,抗PD-L1,抗AKT,抗 pAKT(Ser473)购自美国Cell Signaling公司; 二抗为兔抗鼠抗体,购自美国DAKO公司.用于 《中国癌症杂志》2020年第30卷第6期 流式细胞术分析的FITC标记PD-L1由本实验室 自行偶联;蛋白...
(MSS)呈正相关,而脾 CD3+ CD4+细胞上 PD⁃1 的表达与 MSS 呈负相关.用日本血吸虫可溶性虫卵抗原 (SEA)和可溶性雄虫抗原(SMWA)免疫小鼠后观察到,SEA 免 疫后,脾脏 T 细胞上 PD⁃1 的表达高于 SMWA 免疫,且主要使 DCs 表面的 PD⁃L2 表达上调;SMWA 免疫后,主要表现为 T 细 胞上 PD⁃L1 ...
As the thymocytes migrate further into the cortex of the thymus, the expression of CD3, CD4, CD8 and TCR increases. TCRs with self-reactivity are deleted because of contact with autoantigens presented by dendritic cells and macrophages. This leads to negative selection. Cells that express CD4 ...
Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow Nature. B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 ...
For instance, nanoparticles loaded with chondroitin sulfate were specifically targeting CD44 expressed macrophages to reduce the inflammation in ulcerative colitis both in vitro and in vivo compared to non-coated counterparts [9]. The positively charged chitosan facilitates electrostatic interactions with ...
PS expression on the outer-membrane surface of apoptotic cells is an “eat-me” signal for macrophages and other phagocytic cells. Interestingly, in LA–deficient mice, an increased level of PEVs in the bloodstream is observed, where the level indicates that LA may also play a role in the ...