Parkinson's diseaseNew research indicates that in a mouse model of Parkinson disease, alpha -synuclein is trafficked from the brain to the gut by CD11c-expressing macrophages.doi:10.1038/s41582-023-00910-2Heather WoodNature Reviews Neurology
Results: We found pretreatment of mice with PepN promoted the proliferation of lung-resident F4/80+CD11chigh macrophages in situ but also mobilized bone marrow monocytes to infiltrate lung tissue that were then transformed into CD11high macrophages. PepN pre-programmed the macrophages during maturatio...
“The preprogrammed anti-inflammatory phenotypes of CD11chigh macrophages by Streptococcus pneumoniae aminopeptidase N safeguard from allergic asthma” “肺炎链球菌氨基肽酶N介导CD11c高表达巨噬细胞的预编程抗炎表型保护过敏性哮喘” Abstract: Background: Early microbial exposure is associate with protective allergic...
Conclusion: Our results demonstrated that the expansion of CD11chigh macrophages in lungs and the OXPHOS metabolic bias of macrophages are associated with reduced allergic airway inflammation after PepN exposure, which paves the way for its application in preventing allergic asthma. 摘要: 背景:早期微...
CD11c refers to a component of the heterodimer CD11/CD18 adhesion molecules that is highly expressed in monocytes/macrophages, NK cells, and hairy cells. AI generated definition based on:Atlas of Hematopathology,2013 Also in subject areas: ...
CD11c, also known as integrin αX, is a type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, a subset of B cells, NK cells and dendritic cells (PMID: 2897326; 1680915; 1694698; 17389580). As a result of its high level of expression...
Description :CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin α andCR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed onmonocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells.CD11c has been repor...
The 3.9 monoclonal antibody specifically binds to the human adhesion glycoprotein CD11c, a 150 kDA integrin alpha chain also known as integrin alpha X. It is expressed on macrophages, granulocytes, monocytes, dendritic cells, natural killer cells, and subsets of B and T lymphocytes. The CD11c/CD...
CD11c is a 150 kDa adhesion glycoprotein that associates with beta2 integrin to form the CD11c/CD18 heterodimer that binds CD54 (ICAM-1) and fibrinogen. It is expressed on NK cells, a subset of B and T cells, granulocytes, monocytes, and macrophages. It functions in cytotoxic T cell kill...
CD11c/Integrin alpha X is a 145-150 kDa type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, NK cells and dendritic cells. Integrin alpha X/beta 2 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis. ...