CD11c + macrophages mediate brain-to-gut α-synuclein traffickingNew research indicates that in a mouse model of Parkinson disease, alpha -synuclein is trafficked from the brain to the gut by CD11c-expressing macrophages.Wood, HeatherNature reviews. Neurology...
CD11cis a type Itransmembrane proteinthat is expressed on monocytes,granulocytes, a subset of B cells, dendritic cells, and macrophages and may be demonstrated on B-cellchronic lymphocytic leukemia,marginal zone lymphomas, andhairy cell leukemia. The amount of this antigen is varied with the antige...
(2016). CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23. Mucosal Immunol. 9, 352-363.I. C. Arnold, S. Mathisen, J. Schulthess, C. Danne, A. N... IC Arnold,S Mathisen,J Schulthess,... - 《Mucosal Immu...
Description :CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin α andCR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed onmonocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells.CD11c has been repor...
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger...
The 3.9 monoclonal antibody specifically binds to the human adhesion glycoprotein CD11c, a 150 kDA integrin alpha chain also known as integrin alpha X. It is expressed on macrophages, granulocytes, monocytes, dendritic cells, natural killer cells, and subsets of B and T lymphocytes. The CD11c/CD...
Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages We used a panel of monoclonal antibodies to characterize DCs in the dermis of normal human skin. Staining for the CD11c integrin, which is abundant on many... LC Zaba,J Fuentes-...
CD11c macrophages/dendritic cells (MDCs) are increased and display the classically activated M1-like phenotype in obese adipose tissue (AT) and may contribute to AT inflammation and insulin resistance. Stat1 is a key transcription factor for MDC polarization into the M1-like phenotype. H...
Isotype: Mouse IgG1, κ Reactivity: Human Description CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αXand CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and sub...
CD11c, also known as Integrin alpha X, is an approximately 150 kDa type I transmembrane glycoprotein that heterodimerizes with Integrin beta 2, also known as CD18. The CD11c/CD18 complex, also called CR4 (complement receptor type 4) is expressed on macrophages, dendritic cells and hairy cell...