2. Hartwell, L. H. & Weinert, T. A. Checkpoints: controls that ensure the order of cell cycle events.Science246, 629–634 (1989).3. Magiera, M. M., Gueydon, E. & Schwob, E. DNA replication and spindle checkpoints cooperate during S phase to delay mitosis and preserve genome in...
A. Interphase B. Prophase C. Metaphase D. Anaphase 相关知识点: 试题来源: 解析 A。细胞周期中,间期负责 DNA 复制。间期包括 G1 期、S 期和 G2 期,其中 S 期进行 DNA 复制。前期(B 选项)主要是染色体出现等变化。中期(C 选项)染色体排列在赤道板上。后期(D 选项)姐妹染色单体分离。
Faithful DNA duplication is fundamental for all life forms. Eukaryotic genomes, organized into multiple linear chromosomes of different sizes, present a very complex and intricate framework for DNA replication regulation compared to prokaryotes. A single bidirectional replication origin is sufficient to dire...
and negatively regulates cell cycle S-phase. Consistently, loss and gain of function studies demonstrated that EMP3 inhibits breast cancer cell S-phage entry, DNA replication, DNA damage
Biochemical studies on the replication of the genome of the small DNA virus simian virus 40 (SV40) have resulted in the identification of a number of DNA replication proteins from human cells. One of these, Replication Protein A (RPA), was phosphorylated in a cell cycle-dependent manner, ...
2. Hartwell, L. H. & Weinert, T. A. Checkpoints: controls that ensure the order of cell cycle events.Science246, 629–634 (1989). 3. Magiera, M. M., Gueydon, E. & Schwob, E. DNA replication and spindle checkpoints cooperate during S phase to delay mitosis and preserve genome ...
3. DNA损伤的类型 3.1 内源性DNA损伤3.2 外源性DNA损伤 4. DNA损伤与DNA变异 5. DNA损伤应答(DDR)途径 5.1 DNA修复机制5.2 细胞周期停滞与细胞凋亡 6. DNA损伤与疾病 7. 与DNA损伤修复相关的重组蛋白 1. 什么是DNA损伤?DNA损伤是指任何偏离其原始双螺旋结构的改变。所有细胞生物都会发生DNA损伤。2....
the longest phase during which the cells are preparing for DNA replication; S: the period in the cell cycle which DNA is replicated; G2: preparing for mitosis; M: mitosis and cell division; 3.2 the enzymes and proteins needed in eukaryotic DNA replication 3.2.1 DNA pol α: initiates the ...
Cell , 1993 , 75 4 : 729~739 DNA replication machinery to the S phase checkpoint . Cell , 1995 , 19 Toczyski D P , Galgoczy D J , Hartwell L H. CDC5 and CKII 80 ( 1) : 29~39 control adaption to the yeast DNA checkpoint . Cell , 1997 , 90 10 Peng C H , Graves P...
eukaryotic chromosome replication requires the orchestration of multiple DNA replication origins to ensure that each DNA polymer, irrespective of its size in the cell, is replicated exactly once during S phase of the cell cyc...