This review focuses on the underlying mechanisms that regulate the progression of cells into the DNA replication phase (the G1-S phase transition), since it is at this stage in mammalian cells where cell proliferation is predominantly regulated. To enter into S phase, cells must pass a stage ...
When a cell replicates its DNA during S phase of the cell cycle, the sister chromatid pairs must stick together like glue until they are separated to opposite ends of the cell (and hence into separate daughter cells) at anaphase. How the cell achieves this is still unclear but, as Takahash...
Cells have developed a number of means to respond to these challenges, such as replication-coupled DNA repair pathways and S-phase checkpoint responses that protect the stability of replication forks, inhibit the initiation of replication in new areas of the genome, and block cell cycle progression...
M. Cell-cycle-associated expression patterns predict gene function in Mycobacteria. Curr. Biol. 30, 3961–3971.e6 (2020). Article CAS PubMed PubMed Central Google Scholar Cooper, S. The synchronization manifesto: a critique of whole-culture synchronization. FEBS J. 286, 4650–4656 (2019)....
Mouse hepatitis virus (MHV) replication in actively growing DBT and 17Cl-1 cells resulted in the inhibition of host cellular DNA synthesis and the accumulation of infected cells in the G(0)/G(1) phase of the cell cycle. UV-irradiated MHV failed to inhibit host cellular DNA synthesis. MHV...
Dysregulated DNA replication is a cause and a consequence of aneuploidy in cancer, yet the interplay between copy number alterations (CNAs), replication timing (RT) and cell cycle dynamics remain understudied in aneuploid tumors. We developed a probabili
Proteolysis of DNA Replication Licensing Factor Cdt1 in S-phase Is Performed Independently of Geminin through Its N-terminal Region Licensing of replication origins is carefully regulated in a cell cycle to maintain genome integrity. Using an in vivo ubiquitination assay and temperature... H Nishitani...
Studies with cell cycle inhibitors revealed that cells arrested at the G(1) or G(1)/S phase could express high levels of viral polyprotein and produced abundant infectious virus. In contrast, both protein expression and virus yield were markedly reduced in quiescent ...
Replication origins in eukaryotic cells never fire more than once in a given S phase. Here, we summarize the role of cyclin–dependent kinases in limiting DNA replication origin usage to once per cell cycle in the budding yeast Saccharomyces cerevisiae. We have examined the role of different cyc...
In recent years, the divided genome of Vibrio cholerae has proven ... Saint-Dic,Kehrl,Frushour,... - 《Journal of Bacteriology》 被引量: 28发表: 2008年 EPCO-06. DIFFUSE MIDLINE GLIOMAS: FROM CELL CYCLE TO THERAPEUTIC OPPORTUNITIES The fatal Diffuse Midline Gliomas (DMG) are characterized ...