2. T. M. Gottlieb, M. Oren, p53 and apoptosis. Semin. Cancer Biol. 8, 359–368 (1998).3. J. S. Fridman, S. W. Lowe, Control of apoptosis by p53. Oncogene 22, 9030–9040 (2003).4. W. P. Roos, B. Kaina, DNA damage-induced cell death by apoptosis. Trends Mol. Med. 12...
ApoptosisCell SurvivalSynonyms DNA damage triggered death signaling pathways ; DNA repair and damage processing Definition DNA damage –induced cell death is executed by apoptosis, necrosis, mitotic catastrophe, and autophagy. From these different forms of cell inactivation apoptosis is the main route of...
[33]Saha LK, Wakasugi M, Akter S, et al. Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells[J]. Proc Natl Acad Sci U S A, 2020, 117(25): 14412-14420. DOI: 10.1073/pnas.1920165117. [34]Mullenders L...
DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53WooR...
Unicellular organisms respond to the presence of DNA lesions by activating cell cycle checkpoint and repair mechanisms, while multicellular animals have acquired the further option of eliminating damaged cells by triggering apoptosis. Defects in DNA damage-induced apoptosis contribute to tumorigenesis and to...
DNA damage induced apoptosis is regulated by CLPTM1L.Michael A. JamesWeidong WenYian WangLauren A. ByersJohn V. HeymachKevin R. CoombesLuc GirardJohn MinnaMing You
[19]Seo, J.Y., et al., Heterogeneous nuclear ribonucleoprotein (hnRNP) L promotes DNA damage-induced cell apoptosis by enhancing the translation of p53. Oncotarget, 2017. 8(31): 51108-51122. [20]Adamson, B., et al., A genome-wide homologous recombination screen identifies the RNA-binding...
简述cancer和DNAdamage以及Apoptosis的关系如何。相关知识点: 试题来源: 解析 在多细胞生物体中,细胞的数量保持在一定的量上。这种平衡是通过有丝分裂的细胞增生以及由细胞凋亡引起的细胞死亡来实现的。如果这一平衡被打破,则有可能产生癌变。为了处理DNA损伤,细胞进化出一套复杂的修复系统,如果这套系统失败,则会导致...
-induced DNA damage promoted the formation of PAR and nuclear translocation of apoptosis-inducing factor (AIF), thus activating PARP1-dependent parthanatos in Caco-2 cells and human intestinal organoids. Our work verifies a previously unexplored role for parthanatos in intestinal epithelial damage ...
DDIAS, DNA damage-induced apoptosis suppressor, is a potential therapeutic target in cancer ArticleOpen access01 May 2023 Targeting DNA damage response pathways in cancer A brief introduction to the DNA damage response Genome integrity is a fundamental factor that guarantees the generating healthy and...