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This review will present a summary of a description of apoptotic pathways in the heart, followed by ways to measure it and the experimental and clinical evidence for the role of apoptosis in cardiac disease. An evaluation of the effectiveness of pharmacological and other therapeutic interventions in...
Nicotinic acetylcholine receptor alpha7 and beta4 subunits contribute nicotine-induced apoptosis in periodontal ligament stem cells. Mol Cells. 2012;33(4):343–50. Article PubMed PubMed Central CAS Google Scholar Wang XJ, Liu YF, Wang QY, Tsuruoka M, Ohta K, Wu SX, et al. Functional ...
Paclitaxel is a widely used drug developed since the mid-1980s, with significant antitumor activity against ovarian, head and neck, bladder, breast and lung cancers. Paclitaxel promotes microtubule assembly and stabilizes microtubule dynamics, inhibiting cell proliferation and induction of apoptosis. Pacli...
High doses of radiation cause radiation sickness, cancer and death. But what if low doses of radiation could reduce the risk of developing cancer? Traditional toxicological models of risk assessment assume that as the dose of a harmful substance increases, so too does the risk associated with ...
The acute (sudden) form is much less common, but it does have symptoms and is very serious. An acute attack can cause intense eye pain, blurry vision, and nausea or vomiting. Untreated acute angle-closure glaucoma causes blindness within hours or days. It is a medical emergency that needs...
Effects of the combined treatment of bone marrow stromal cells with mild exercise and thyroid hormone on brain damage and apoptosis in a mouse focal cerebral ischemia model. Metab Brain Dis. 2017;32(4):1267–77. Article CAS PubMed Google Scholar Akhoundzadeh K, Vakili A, Sameni HR. Bone...
It can also inhibit apoptosis to maintain endometrial growth [10]. G-CSF also plays an essential role in embryo implantation by regulating the expression of genes associated with embryo adhesion, cell migration, tissue remodeling and angiogenesis, which are essential for endometrial growth, successful...
This supposition is controvertible but supported by preclinical research showing that sulfonylureas promote beta cell death/apoptosis [90, 91]. It is the opinion of these authors that high levels of sulfonylurea-induced insulin secretion in already overworked beta cells should be eschewed, especially ...
In contrast, miR-766 can inhibit the cell cycle by enhancing the function of p53 [89]. In addition, some studies have shown that increasing the expression of miR-203 and miR-22 in colon cancer cells with a mutation inTP53can cause induction of apoptosis, inhibition of proliferation, decrease...