Apoptosis in cardiac disease-what is it-how does it occur. Cardiovasc Drugs Ther 15: 507- 523, 2001.Neuss M, Crow MT, Chesley A and Lakatta EG. Apoptosis in cardiac disease--what is it--how does it occur. Cardiovasc Drugs Ther 15: 507-23, 2001....
This review will present a summary of a description of apoptotic pathways in the heart, followed by ways to measure it and the experimental and clinical evidence for the role of apoptosis in cardiac disease. An evaluation of the effectiveness of pharmacological and other therapeutic interventions in...
(plus additional oncogenic lesions) causes apoptosis in lymphoma cells but cell senescence and cell cycle arrest in solid organ cancers.101–104 Importantly, there is evidence that p53 activation and expression may occur without necessarily resulting in apoptosis or senescence, as has been observed in...
factors such as TNFa, ceramide or Fas-receptor ligation, ROCK1 cleavage and activation are relatively late events,6,7 consequently ROCK inhibition does not halt the apoptotic process.6 However, in some contexts chronic or high-intensity ROCK activity may contribute to the initiation of apoptosis. ...
Moreover, autoantibodies and CTLs interfere with megakaryocyte maturation and apoptosis, leading to decreased platelet production in ITP. AMR Ashwell–Morell receptor, FcγR Fcγ receptor, M1/M2 M1/M2 macrophage polarization, CDC complement-dependent cytotoxicity, AICD activation-induced cell death, DC...
Gefitinib has a favorable toxicity profile compared to chemotherapy. Common side effects include skin rash, diarrhea, and nausea, which are generally reversible and occur within the first month of therapy. Hepatotoxicity, asymptomatic liver enzyme elevation, is rare and resolves upon discontinuation of ...
How does involution occur? Involution isthe shrinking or return of an organ to a former size. At a cellular level, involution is characterized by the process of proteolysis of the basement membrane (basal lamina), leading to epithelial regression and apoptosis, with accompanying stromal fibrosis. ...
Most of the time, cells are able to detect and repair DNA damage. If a cell is severely damaged and cannot repair itself, it undergoes so-called programmed cell death or apoptosis. Cancer occurs when damaged cells grow, divide, and spread abnormally instead of self-destructing as they should...
We have discovered that even though ibrutinib does not elicit frank cell death, it can increase mitochondrial BCL-2 dependence, and sensitize CLL cells to the BCL-2 inhibitor venetoclax114. Thus, by increasing our understanding of the mechanism of action of novel agents on apoptosis, BH3 ...
Regulated cell death fulfils a biological function The terms 'programmed' or 'regulated' imply that these processes occur within a (patho) physiological context and fulfil biological functions. When this regulated cell death criterion is applied it is obvious that apoptosis has a range of biological...