Voltage clamp analysis revealed that all three Cav-3 mutants caused a fivefold increase in late sodium current (Table 4). PATHOGENETIC MECHANISMS OF MUSCLE TISSUE DAMAGE IN CAVEOLIN-3 DEFICIENCY Most of CAV3 mutations cause a severe loss of Cav-3 protein as shown both by immunohistochemistry ...
Lysosomal storage diseases (LSDs) are a group of over 70 diseases that are characterized by lysosomal dysfunction, most of which are inherited as autosomal recessive traits. These disorders are individually rare but collectively affect 1 in 5,000 live births. LSDs typically present in infancy and...
Deletion of the miR-17–92 cluster in B cells in mice caused enhanced homing of plasma cells to the bone marrow upon TD immunization, likely owing to the effect of miR-17–92 on S1pr1, a gene important for the egress of lymphocytes from the lymphoid organs [56]. miRNAs in B cell ...
Various diseases are caused by or related to abnormal accumulation of proteins and damaged organelles. Since autophagy exerts essential functions in degrading superfluous proteins and organelles, the role of autophagy in the physio-pathologic process of many diseases have been investigated. Until now, al...
by upregulating GPX4 [133]. Qingyi decoction (QYD) is a robust anti-inflammatory agent that can improve the intestinal barrier damage caused by SAP, microcirculatory disorders, and pulmonary inflammatory response and has been shown to inhibit both ferroptosis and apoptosis by enhancing the activity ...
The failure of cells to adapt to the changes in redox homeostasis and the subsequent cell death, together with the damage caused by inflammatory mediators... N Bakunina,CM Pariante,PA Zunszain - 《Free Radical Biology & Medicine》 被引量: 136发表: 2015年 Metabolic features of the cell da...
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD), food allergy (FA), and eczema are systemic diseases caused by an impaired immune system. Accompanied by high recurrence rates, the steadily rising incidence
an advanced form of age-related macular degeneration caused by degeneration of the retinal pigment epithelium (RPE).99In addition, due to changes in heterochromatin, neurodegeneration-associated proteins are tightly related to the derepression of repetitive element transcription.100Saldi et al. reported ...
This improves retinal microvascular dysfunction caused by diabetes. It offers a potential therapeutic target for DR treatment. EVs secreted by MSCs inhibit the inflammation response, angiogenesis, and apoptosis by shuttling between cells to repress DR progression. He et al. found that EVs secreted ...
attenuating ATP loss in BEAS-2B cells caused by cigarette smoke medium [130]. By coculturing WJMSCs with mtDNA-deficient ρ0 cells, WJMSCs were able to transfer their mitochondria to ρ0 cells and restore the expression of mitochondrial protein-encoding genes and the activity of the electron ...