Because citrullination, whether by means of apoptosis or by some other mechanism, is a natural phenomenon, those neo-antigens would need to occur in ... HA Ménard,E Lapointe,MD Rochdi,... - 《Arthritis Research & Therapy》 被引量: 361发表: 2000年 Autophagy promotes necrosis in apoptosis-...
Intrinsic apoptosis is controlled by the BCL-2 family of proteins but the complexity of intra-family interactions makes it challenging to predict cell fate via standard molecular biology techniques. We discuss BCL-2 family regulation and how to determine cells’ readiness for apoptosis and anti-apopt...
The tumor suppressor gene p53 (Tp53) mutations pay central role in the development and biology of HGSC. The loss-of-function mutations of TP53 occur in close to 100% of HGSC cases [110]. There is accumulating evidence that the wild type TP53 not only prevents tumorigenesis by regulating the...
Many neurons undergo apoptosis following injury, especially if the lesion is close to their cell bodies. Presumably, this was because axotomized neurons are deprived of the trophic support which is normally provided 819 820 Bcl-2 in the regulation of nerve regeneration DF Chen and S Tonegawa by ...
The presence of karyotypically abnormal stromal cells and granulosa cells of small follicles and the high rates of germ cell apoptosis of small follicles that occur in females with TS could have an adverse effect on the success rate of autotransplantation of ovarian cortex tissue in this patient ...
These and many other similar results show that curcumin stops lung cancer cells from growing and migrating by “turning off” multiple mechanisms inside them that would otherwise have allowed them to grow uncontrollably. If you’d like to incorporate curcumin into your diet, remember that it is ...
Third, the switch back to sex-specific organelle exclusion (uniparental inheritance) should occur by diverse mechanisms that can differ between closely related species or even between haplotypes. Strikingly, these patterns are indeed observed, throughout the eukaryotic domain (Box 3; Fig...
Such yeast infections can occur if conditions in the body are favorable for yeast overgrowth. Potential risk factors for recurrent vaginal yeast infections have been extensively studied. Recurrent infections may be caused by the resistance of non - C. albicans species, such as Candida glabrata or ...
The therapeutic rationale for these inhibitors is that in a p53 non-functional tumour cell, radiosensitisation or chemosensitisation would occur as both the G1 and G2 checkpoints would be abrogated. In normal cells, damage due to chemotherapeutic agents or radiation would be minimised due to the...
These beneficial effects are thought to occur through several mechanisms, including stopping the cell cycle (which prevents cancer cells from dividing), inhibiting the spread of cancer cells, triggering programmed cell death (apoptosis), blocking the formation of new blood vessels (anti-angiogenesis),...