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DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these agents induce a plethora of different DNA lesions, it is firstly ... WP Roos,B Kaina - 《Cancer Letters...
Cell SurvivalSynonyms DNA damage triggered death signaling pathways ; DNA repair and damage processing Definition DNA damage –induced cell death is executed by apoptosis, necrosis, mitotic catastrophe, and autophagy. From these different forms of cell inactivation apoptosis is the main route of death ...
DNA damage-induced cell death by apoptosis. Following the induction of DNA damage, a prominent route of cell inactivation is apoptosis. During the last ten years, specific DNA lesions that trigger ap... WP Roos - 《Trends in Molecular Medicine》 被引量: 1794发表: 2006年 Lysine Methylation ...
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Canthin-6-one Cell death Apoptosis Necroptosis DNA damage 1. Introduction AML is a malignant myeloid disease of the stem cell precursors of the myeloid lineage characterized by the clonal expansion of blasts with incomplete cell differentiation [1]. In turn, a reduction in the number of healthy ...
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Hydrogen peroxide (H2O2)-induced DNA damage and cell death have been attributed to the direct cytotoxicity of H2O2 and other oxidant species generated from H2O2. We examined the possibility that oxidants activate endonucleases leading to DNA damage and cell death in renal tubular epithelial cells, si...
[11]Vitale I, Manic G, De Maria R, et al. DNA damage in stem cells[J]. Mol Cell, 2017, 66(3): 306-319. DOI: 10.1016/j.molcel.2017.04.006. [12]Mianné J, Nasri A, Van CN, et al. CRISPR/Cas9-mediated gene knockout...
Unicellular organisms respond to the presence of DNA lesions by activating cell cycle checkpoint and repair mechanisms, while multicellular animals have acquired the further option of eliminating damaged cells by triggering apoptosis. Defects in DNA damage-induced apoptosis contribute to tumorigenesis and to...