简述cancer和DNAdamage以及Apoptosis的关系如何。相关知识点: 试题来源: 解析 在多细胞生物体中,细胞的数量保持在一定的量上。这种平衡是通过有丝分裂的细胞增生以及由细胞凋亡引起的细胞死亡来实现的。如果这一平衡被打破,则有可能产生癌变。为了处理DNA损伤,细胞进化出一套复杂的修复系统,如果这套系统失败,则会导致...
2024年5月16日，来自阿姆斯特丹荷兰癌症研究所生物化学部Thijn R. Brummelkamp团队在Science上发表了题为DNA damage induces p53-independent apoptosis through ribosome stalling的文章。研究发现了p53非依赖的DNA损伤诱导细胞凋亡的信号。作者发现核糖体在稀少亮氨酸编码UUA密码子上停滞，并在全局范围内限制了翻译的启动。
Editorial. Comments on the mechanisms that link DNA damage and apoptosis. Role of the tumor suppressor protein p53 in the link between DNA damage and apoptosis; Rules that govern the connection between DNA damage and apoptosis operating on the identified platform of lesion-sensors, signal ...
摘要 In response to excessive DNA damage, human cells can activate p53 to induce apoptosis. Cells lacking p53 can still undergo apoptosis upon DNA damage, yet the responsible pathways are unknown. We observed that p53-independent apoptosis in response to DNA damage coincided with translation inhibiti...
[9]Behrens A, van Deursen JM, Rudolph KL, et al. Impact of genomic damage and ageing on stem cell function[J]. Nat Cell Biol, 2014, 16(3): 201-207. DOI: 10.1038/ncb2928. [10]Blanpain C, Mohrin M, Sotiropoulou PA, et ...
Based on our observations, it is considered that METH induces oxidative DNA damage in the brain, especially in the accumben. However, those DNA damage might be caused differently between acute and chronic administration. 展开 关键词: methamphetamine neurotoxicity peroxidative DNA damage 8-OH-dG ...
Proper chromatin function and maintenance of genomic stability depends on spatiotemporal coordination between the transcription and replication machinery. Loss of this coordination can lead to DNA damage from increased transcription-replication collision
Apoptosis, Cell Signaling, and Human Diseases Volume 739 || DNA Damage-Dependent Apoptosis The rad-51 gene in Caenorhabditis elegans is transcribed into alternative mRNAs potentially coding three alternative protein isoforms. We have genetically modified this gene in order to investigate the potential ro...
In subject area: Agricultural and Biological Sciences DNA damage is an alteration in the chemical structure of DNA such as a chemically changed base, a base missing, or a break in a strand of DNA. From: Advances in Clinical Chemistry, 2022 ...
关键词:肿瘤;DNA 损伤修复;放疗;放射敏感性;机制 中图分类号:Q691 文献标识码:R 文章编号:1004-714X(2020)04-0442-04 DNA damage repair and radiosensitivity of tumor YANG Siqi1,YAO Yi1,2,SONG Qibin1,2,ZHENG Sihao2,GAO Yanjun1,2,WU Bin1 1. Cancer Center, Wuhan University ...