In the TME, the major protumor function of TAMs is the production of diverse cytokines and growth factors that support the survival and proliferation of cancer cells, suppress their apoptosis, and increase their migratory potential needed for cancer cell invasion and extravasation into the circulation...
Dissociation between cell cycle arrest and apoptosis can occur in Li-Fraumeni cells heterozygous for p53 gene mutations. Oncogene 1997;14:2137- 47.Delia D, Goi K, Mizutani S, Yamada T, Aiello A, Fontanella E, Lamorte G, Iwata S, Ishioka C, Krajewski S, Reed JC and Pierotti MA (1997)...
Soluble VCAM-1 binding to ␣4 integrins is cell-type specific and activation dependent and is disrupted during apoptosis in T cells Soluble vascular cell adhesion molecule-1 (sVCAM-1) is generated during inflammation and can alter lymphocyte functions. The authors report that the binding of sVCAM...
BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of the mitochondrial outer membrane. Their transition from quiescent monomers to pore-forming oligomers involves a well-characterized symmetric dimer intermediate. However, no essenti...
In the TME, the major protumor function of TAMs is the production of diverse cytokines and growth factors that support the survival and proliferation of cancer cells, suppress their apoptosis, and increase their migratory potential needed for cancer cell invasion and extravasation into the circulation...
It is worth noting that the severity of these adverse effects appeared to be greater in the obese mice than non-obese mice. Moreover, TiO2 NPs disordered the expression of genes and proteins related to spermatogenesis, ooge...
Newresearchhas also shown that a properly functioning circadian rhythm can make treatment more effective, but a disruption may increase the chance of drug resistance. The circadian rhythm plays a role in cell fate, which is why more and more treatments are being timed to increase apoptosis (cell...
Inflammation may contribute to cancer development through numerous mechanisms, including DNA damage, angiogenesis, promotion of cellular proliferation, and inhibition of apoptosis [26]. Indeed, inflammatory conditions of the esophagus, specifically reflux esophagitis and BE, have been implicated in the ...
WNT–β-catenin signalling is involved in a multitude of developmental processes and the maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation, migration, genetic stability and apoptosis, as well as by maintaining adult stem cells in a pluripotent state. Not surprisingl...
Caspase activity is not always linked to apoptosis, but is required during development and normal cell differentiation (Busso et al., 2010; Rudrapatna et al., 2013). Moreover such caspase activity can be readily detected in differentiating lens cells (Weber and Menko, 2005). Therefore whilst ...