首页 / 癌基因 / TP53 / DNA BINDING DOMAIN MUTATIONTP53(tumor protein p53) P53基因编码的是分子量约为53kDa的蛋白,P35根据其分子量大小命名的,首次是在1979年发现致瘤病毒SV40可以与该蛋白形成复合物,并且将克隆得到p53转入到细胞可引起细胞癌变,所以最初的10年普遍认为p53是抑癌基因。后来发现之前肿瘤细胞...
To reveal the role of each DNA-binding domain of p53 in these processes, we investigated two p53 mutants lacking either of two DNA-binding domains; structured core and disordered C-terminal domains, using sub-millisecond single-molecule fluorescence microscopy. We found that the C-terminal domain...
Defining the p53 DNA-binding domain/Bcl-XL-binding interface using NMR. FEBS Lett. 559 : 171-174.Petros A. M., Gunasekera A., Xu N., Olejniczak E. T. & Fesik S. W. Defining the p53 DNA-binding domain/Bcl-x(L)-binding interface using NMR . FEBS Lett 559 , 171–174 (2004)....
Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core. Protein Eng. Des. Sel. 22 (7), 421-430.Khoo KH, Joerger AC, Freund SM, Fersht AR (2009) Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core. Protein Eng Des Sel 22...
a我们应将主要以力集中在周围 We should mainly concentrate by the strength in periphery[translate] acollection of monomeric units, and bond-forming processes[translate] aligand to the DNA-binding domain of the p53 transcription factor.[translate]...
1.1 p53及其突变类型 TP53(tumor protein p53)作为肿瘤抑制基因主要由11个外显子及10个内含子构成,其编码的p53蛋白由393个氨基酸残基组成,包含了五大功能结构域:N端反式激活结构域(transcription activation domain,TAD)、富含脯氨酸结构域(proline-rich domain,PRD)、核心DNA结合结构域(DNA-binding domain,DBD,p53C...
aforeign clrade 外国clrade[translate] aI won't let tomorrow Slip away 我明天不会让滑倒[translate] aon fighting for 在战斗为[translate] aligand to the DNA-binding domain of the p53 transcription factor ligand到p53副本因素的脱氧核糖核酸束缚的领域[translate]...
In the first scenario, the C-terminal domain provides multiple nonspecific p53–DNA interactions that stabilize the binary complex (i.e., the lysine residues function simply as an anchor set on each side of the corresponding binding site to provide extra stabilization). The second possibility is ...
The code structure of the p53 DNA-binding domain and the prognosis of breast cancer patients.Motivation: The tumor-suppressor gene TP53 mutations are diverse in the central region encoding the DNA-binding domain. It has not been clear whether the prognostic significance for survival in breast ...
Mol. Biol.》期刊文章:A Conserved G4 DNA Binding Domain in RecQ Family Helicases。 摘要 RecQ家族解旋酶在基因组中富含G的区域发挥重要作用,包括端粒、rDNA和免疫球蛋白开关区。这似乎反映了这个家族中酶解G4 DNA的不寻常能力。RecQ家族解旋酶如何识别这种底物尚未确定。在这里我们表明G4 DNA是长DNA分子背景下...