TP53 DNA binding domain mutational status and rituximabbased treatment are independent prognostic factors for pediatric Burkitt lymphoma patients stratificationdoi:10.3324/haematol.2023.284868Gaia MartireFederica LovisaElisa CarraroDomenico RizzatoSimone Cesaro...
本发明的原理是:具有生物学和临床意义的tp53突变主要是错义突变,而这些突变的分布不是随机的,dna结合区域(dna-bindingdomain,dbd)的突变发生比例高于其他区域,而且其中r175、g245、r248、r249、r273及r282被认为是最常见且最具有临床意义的热点突变。这些有意义的突变位点绝大多数都是由g到a或c到t的碱基突变所导...
1.1 p53及其突变类型 TP53(tumor protein p53)作为肿瘤抑制基因主要由11个外显子及10个内含子构成,其编码的p53蛋白由393个氨基酸残基组成,包含了五大功能结构域:N端反式激活结构域(transcription activation domain,TAD)、富含脯氨酸结构域(proline-rich domain,PRD)、核心DNA结合结构域(DNA-binding domain,DBD,p53C)...
et al. Establishment and characterization of three stable Basal/HER2-positive breast cancer cell lines derived from Chinese breast carcinoma with identical missense mutations in the DNA-binding domain of TP53. Cancer Cell Int 18, 118 (2018). https://doi.org/10.1186/s12935-018-0617-9 Download ...
In the present study, we performed TP53 DNA binding domain (DBD) mutational analysis on a very large pediatric BL cohort. By multivariate analysis, we demonstrated the independent prognostic impact of TP53 mutational status for the early identification of BL patients at higher risk of treatment ...
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phe- notype: lessons from recent developments in the IARC TP53 database. Hum Mutat 2007; 28: 622–629. 2 Leroy B, Fournier JL, Ishioka C, Monti P, Inga A, Fronza G et al. The TP53 website: an integrative...
The TP53 gene is inactivated by mutation in about half of all human cancers [1, 3, 4]. Most oncogenic p53 mutations are missense mutations in the highly conserved DNA- binding domain (DBD) [5, 6] and have been classified as either DNA-contact mutations or structural mutations [7–9]. ...
The code structure of the p53 DNA-binding domain and the prognosis of breast cancer patients.Motivation: The tumor-suppressor gene TP53 mutations are diverse in the central region encoding the DNA-binding domain. It has not been clear whether the prognostic significance for survival in breast ...
230—258)结构的影响.采用GROMACS软件包和GROMOS43A1分子力场,分别对野生型wtP53肽段、单点 突变型P53.R249S肽段、两点突变型P53.R249S/R248W肽段和三点突变型P53-R249S/R248W/G245S肽 段进行了4组独立的分子动力学模拟,每组体系模拟时间为500ns.研究结果表明:R249S单残基突变影响肽 ...
Of the many cellular responses activated by TP53, which ones are critical for tumour suppression? Article 08 April 2022 Targeting p53 pathways: mechanisms, structures and advances in therapy Article Open access 01 March 2023 Shifting the paradigms for tumor suppression: lessons from the p53 fi...