在体外实验中,TONSL-MMS22L复合物具有组蛋白伴侣活性,TONSL的N端的锚蛋白重复域(ankyrin repeat domain,ARD)介导其与H3-H4的相互作用。对ARD与Mcm2组蛋白结合结构域(histone-binding domain,HBD)形成的复合物进行结构分析,发现ARD识别未甲基化的H4K20(H4K20me0),H4K20me0是新生H4的标志。TONSL结合H4K20me...
Is VP64 a DNA-binding protein? What are the main enzymes used by molecular biologists to manipulate DNA? What is the function of the enzyme DNA polymerase? What is the function of tRNA in protein synthesis? What is the role of proteins in a chromosome? What is a DNA binding domain? How...
Although a clear answer to the meaning of this interaction with DNA is lacking at present, most interesting is the proposal of Cherny et al., that α-synuclein may interact with histone-free segments of DNA which are transcriptionally active, and that this interaction might bring about a ...
xeroderma pigmentosaC, E [DNA damage binding protein 2 (DDB2)] XPCXPE Global genomic NER repairs damage in both transcribed and untranscribed DNA [100, 101] Skin cancer (melanoma and non-melanoma) [100, 101] xeroderma pigmentosaA, B, D, F, G XPA XPB XPD XPF XPG Transcription coupled ...
wherein R1 has the meaning as defined under formula (I) and R3 is a linker group as defined under formula (I) for R2 further carrying a reactive functional group, with a label L as defined under formula (I) or a reactive derivative thereof, or (B) reaction of a compound of formula...
Methyl-CpG-binding domain UHRF: Ubiquitin-like containing PHD and RING finger domains 5hmC: 5-hydroxymethylcytosine P: Phosphate CpG: Cytosine-phosphate-guanine CGI: CpG island 6mA: N6-methyladenine 4mC: N4-methylcytosine 5fC: 5-formylcytosine ...
To evaluate the mean nonspecific binding time τ1D, we numerically integrated the survival probability SP distribution and found τ1D to be ∼2 s, consistent with FRAP observations (Supplementary Note 6). Given that τ3D∼3τ1D, the mean 3D diffusion time is ∼6 s, meaning that th...
7.Does transient loss of the nucleosome landscape have any biological meaning in the maintenance of cell identity during division? 8.How, and to what extent, does DNA replication-coupled nucleosome assembly regulate cell fate and differentiation? Do factors responsible for distinct steps of nucleosome...
Mutation of E2F1 K161/164 does not comple- tely abolish E2F1 K63 ubiquitination profile (Figure 2d) meaning that other lysine residues may be conjugated with K63 ubiquitin chains. In summary, we demonstrated that cIAP1 as an E3-ubiquitin ligase is able to promote the accumulation of E2F1 K...
The meaning and scope of the terms should be clear; in the event, however of any latent ambiguity, definitions provided herein take precedent over any dictionary or extrinsic definition. Further, unless otherwise required by context, singular terms shall include pluralities and plural terms shall ...