LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins. Conserved in a variety of evolutionarily divergent plant species, LOB DOMAIN (LBD) genes define a large, plant-specific family of largely unknown function... Aman,Husbands...
This led us to hypothesize that the DBDs from diverse nuclear receptors can function as an NES. We tested this hypothesis by analyzing the export activity of DBDs from steroid, nonsteroid, and orphan nuclear receptors. We found that nuclear export of the GFP reporter was conferred by the DBD...
The starting protein of eukaryotes is the origin recognition complex (ORC), which consists of six subunits (ORC 1-6). In addition, there are cofactors Cdc6 and Cdt1. The complex has a prokaryotic initiation protein AAA+ and wing helix domain, and has a DNA binding function. Fig. 18 E....
We found that the DNA-binding and FANCM-interacting functions of FAAP24, although both require the C-terminal (HhH)2 domain, can be distinguished by segregation-of-function mutations. These results demonstrate dual roles of FAAP24 in DNA damage response against crosslinking lesions, one through ...
The transmembrane DNA-binding protein CadC of E. coli, a representative of the ToxR-like receptor family, combines input and effector domains for signal sensing and transcriptional activation, respectively, in a single protein, thus representing one of t
Prediction of DNA Binding Residues and DNA Binding Proteins The binding of DNA to the protein is very specific where DNA binds to a particular region of the protein usually termed as the binding site, defined by the group of residues that are essential for the biological function and whose mut...
以往的研究表明，多个复制体因子具有组蛋白分子伴侣活性，并参与组蛋白到新生链的转运和分配。例如，Mcm2亚基的N末端延伸结构域（N-terminal extension，NTE）中含有一段保守的组蛋白结合结构域（histone binding domain，HBD），能够以模拟DNA结合的方式缠绕组蛋白(H3-H4)2四聚体并促进其分配至新生DNA滞后链【10,11...
The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors 来自 国家科技图书文献中心 喜欢 0 阅读量: 28 作者:D Qi,A Ren,JO Westholm,AA Serganov,EC Lai 摘要: CSL [CBF-1, Su(H), Lag-1]-type transcription factors are the primary effectors...
以往的研究表明,多个复制体因子具有组蛋白分子伴侣活性,并参与组蛋白到新生链的转运和分配。例如,Mcm2亚基的N末端延伸结构域(N-terminal extension,NTE)中含有一段保守的组蛋白结合结构域(histone binding domain,HBD),能够以模拟DNA结合...
loss-of-function IPEX mutation that induces domain-swap dimerization22, showed significantly reduced affinity for T3G repeats (Extended Data Fig.2h). Fig. 2: FOXP3 forms a ladder-like multimer after binding to T3G repeat DNA. a, The cryo-EM structure of a FOXP3(∆N) decamer in a ...