This article explores the little-known role of the guanylate kinase-associated protein (GKAP), encoded by the Disks large-associated protein 1 (DLGAP1) gene, in NSCLC along with assessing microRNA-30a-5p's influence on DLGAP1 gene expression in the A549 cell line. Materials and Methods: ...
Gene ID (NCBI) 9229 Alternative Names DAP-1;DAP-1-ALPHA;DAP-1-BETA;DAP1;DLGAP1A;DLGAP1B;GKAP;SAPAP1 Application Notes: The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user. ...
Human GeneID(s): 9229 Important Comments: This antibody is expected to recognize both reported isoforms (NP_001003809.1; NP_004737.2) Immunogen Peptide with sequence C-KISNEHSPKLQIRSH, from the internal region of the protein sequence according to NP_004737.2; NP_001003809.1. Please note the pept...
A Genome-Wide Association Study Identifies a Novel Susceptibility Locus at The DLGAP1 Gene For Resistant Hypertension in The Japanese PopulationGenetic association studyGenetics researchHypertensionNumerous genetic variants associated with hypertension and blood pressure are known, but there is a paucity of ...
We have identified the DLGAP1 gene, a member of the Scribble cell polarity complex, as one of the most prominent positive candidates. Analyses in hematopoietic cell lines revealed DLGAP1 centrosomal and cytoplasmic localization. The centrosomal localization of DLGAP1 was cell cycle dependent and ...
The lead SNP (rs1442386) of the most significant association locus achieving genome-wide significance in this study was in the intron region of theDLGAP1gene, which is exclusively expressed in brain and encodes disks large-associated protein 137. This variant is putatively GCM motif-altering, and...
Despite variants in theDlgap1gene having the two lowestp-value in a genome-wide association study of obsessive compulsive disorder (OCD), previous studies reported the absence of OCD-like phenotypes inDlgap1knockout (KO) mice. Since these studies observed behavioral phenotypes only for a short ...
Dlgap1ProliferationApoptosisBrown fatWhite fatIsolation and characterization of white and brown adipocytes. White fat and brown adipose tissue, left; cultured white and brown adipocytes, right. Results of RT-qPCR on marker genes of white and brown adipocytes. White-fat marker gene, left; brown-fat...
The expression of DEAD-box helicase 59 (DDX59) was quantified using western blotting, and a dual-luciferase reporter gene assay was performed to detect the interaction between DLGAP1-AS1 and miR-628-5p. Results The authors observed increased DLGAP1-AS1 expression in glioma tissues and cell ...
miR-744-3p细胞侵袭细胞周期目的探讨长链非编码RNA(long non-coding RNA,lncRNA)DLGAP1-AS1对骨肉瘤细胞侵袭和细胞周期的影响及可能的机制.方法采用基因表达谱交互式分析(Gene Expression Profiling Interactive Analysis,GEPIA)数据库分析DLGAP1-AS1表达水平与骨肉瘤患者生存率的关系.qRT-PCR检测骨肉瘤细胞Saos2,HOS,U...